Gene Therapy for Head and Neck Cancer
Gene Therapy for Head and Neck Cancer
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DOI：
10.1159/000322490
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
O'Malley, Bert W., Jr.
中科院分区：
文献类型：
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作者：
Abuzeid, Waleed M.;Li, Daqing;O'Malley, Bert W., Jr.
尽管手术、放疗和化疗取得了进展，但与头颈癌相关的死亡率在过去几十年中基本保持不变。基因治疗是一种新的治疗方法，可能会潜在地推进遗传性疾病的治疗，包括恶性肿瘤，如头颈癌。已经开发了多种载体系统，其促进将治疗性遗传物质引入细胞中。这些包括基于DNA的载体、病毒载体以及最近诱导RNA干扰的载体。基因治疗策略可分为3组：（1）旨在直接诱导细胞死亡的细胞减少疗法，（2）旨在修复恶性肿瘤潜在遗传缺陷的矫正疗法，以及（3）促进针对癌细胞的强大免疫应答的免疫调节。转化研究已在这些领域中的每一个进行，最终在临床试验和实施基因治疗作为一个可行的治疗方式的头部和颈部癌症。版权所有（C）2011 S. Karger AG，巴塞尔
The mortality associated with head and neck cancer has remained largely unchanged for the past several decades despite advancements in surgery, radiotherapy and chemotherapy. Gene therapy is a novel treatment approach that may potentially advance the treatment of genetic diseases, which include malignancies such as head and neck cancer. Multiple vector systems have been developed that facilitate the introduction of therapeutic genetic material into cells. These include DNA-based vectors, viral vectors and, most recently, vectors that induce RNA interference. Gene therapy strategies can be classified in 3 groups: (1) cytoreductive therapy aimed at directly inducing cell death, (2) corrective therapy intended to repair genetic defects underlying malignancy, and (3) immune modulation to promote a robust immune response against cancer cells. Translational research has been conducted in each of these areas, culminating in clinical trials and the implementation of gene therapy as a viable therapeutic modality for head and neck cancers. Copyright (C) 2011 S. Karger AG, Basel