Comparison of Catabolic Rates of sn-1, sn-2, and sn-3 Fatty Acids in Triacylglycerols Using 13CO2 Breath Test in Mice.
Comparison of Catabolic Rates of sn-1, sn-2, and sn-3 Fatty Acids in Triacylglycerols Using 13CO2 Breath Test in Mice.
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使用小鼠 13CO2 呼气试验比较三酰甘油中 sn-1、sn-2 和 sn-3 脂肪酸的分解代谢率。
DOI：
10.5650/jos.ess16124
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发表时间：
2017
影响因子：
1.5
通讯作者：
N. Gotoh
中科院分区：
文献类型：
--
作者：
Fumiaki Beppu;T. Kawamatsu;Yoshio Yamatani;T. Nagai;Kazuaki Yoshinaga;H. Mizobe;Akihiko Yoshida;A. Kubo;J. Kanda;N. Gotoh
三酰甘油(TAG)中的脂肪酸在消化后被分解。然而，TAG的sn-1、sn-2和sn-3位的脂肪酸的分解代谢率还没有被比较。为了解释这些差异，我们使用同位素比质谱仪研究了13C标记的棕榈酸、油酸和戊酸在标签的sn-1、sn-2或sn-3位置的分解代谢速率。具体来说，我们测量了小鼠呼出的二氧化碳(Δ13C(‰))中13C与12C的比率。对于所有分析的脂肪酸，我们观察到sn-2和其他结合位置之间的显著差异。相比之下，sn-1和sn-3位置之间没有明显差异。这些结果表明，脂肪酸的分解代谢率强烈地受到它们在标签中的位置的影响。
Fatty acids in triacylglycerols (TAGs) are catabolized after digestion. However, the catabolic rates of the fatty acids at the sn-1, sn-2, and sn-3 positions of TAGs have not been compared. To elucidate the differences, we studied the catabolic rates of 13C-labeled palmitic acid, oleic acid, and capric acid at the sn-1, sn-2, or sn-3 position of TAGs using isotope-ratio mass spectrometry. Specifically, we measured the 13C-to-12C ratio in CO2 (Δ13C (‰)) exhaled by mice. For all analyzed fatty acids, we observed significant differences between sn-2 and other binding positions. In contrast, no significant difference was detected between the sn-1 and sn-3 positions. These results indicated that the catabolic rates of fatty acids are strongly influenced by their positions in TAGs.
DOI：
10.1152/ajpgi.00387.2010
发表时间：
2011-04-01
影响因子：
4.5
作者：
Wang, Yu;Chandra, Rashmi;Liddle, Rodger A.
通讯作者：
Liddle, Rodger A.
影响因子：
15.9
作者：
LIDDLE, RA;MORITA, ET;WILLIAMS, JA
通讯作者：
WILLIAMS, JA