The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.
The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.
复制标题
12/15-脂氧酶是阿尔茨海默氏病的新兴治疗靶点。
DOI：
10.1016/j.tips.2015.01.005
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发表时间：
2015-03
影响因子：
13.8
通讯作者：
Pratico, Domenico
中科院分区：
文献类型：
--
作者：
Joshi, Yash B.;Giannopoulos, Phillip F.;Pratico, Domenico
关键词：
Alzheimer's disease (AD) is a chronic neurodegenerative condition characterized by progressive memory. Mutations in genes involved in the production of amyloid-β (Aβ) are linked to the early-onset variant of AD. However, the most common form, sporadic AD, is considered the result of an interaction between environmental risk factors and various genes. Among them, recent work has highlighted the potential role that the 12/15Lipoxygenase (12/15LO) pathway may play in AD pathogenesis. 12/15LO is widely distributed in the central nervous system, and its levels are up-regulated in patients with AD or mild cognitive impairments. Studies using animal models implicated 12/15LO in the molecular pathology of AD, including the metabolism of Aβ and tau, synaptic integrity and cognitive functions. Here, we will provide an overview of this pathway and its relevance to AD pathogenesis, discuss the mechanism(s) involved, and provide an assessment of how targeting 12/15LO could lead to novel AD therapeutics.
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影响因子：
2.1
作者：
LeBlanc, Andrea C.
通讯作者：
LeBlanc, Andrea C.
DOI：
10.1523/jneurosci.2168-09.2010
发表时间：
2010-02-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
DeCostanzo AJ;Voloshyna I;Rosen ZB;Feinmark SJ;Siegelbaum SA
通讯作者：
Siegelbaum SA
影响因子：
4.7
作者：
Niizuma K;Endo H;Chan PH
通讯作者：
Chan PH
影响因子：
7.7
作者：
McDuffie, Marcia;Maybee, Nelly A.;Nadler, Jerry L.
通讯作者：
Nadler, Jerry L.
影响因子：
3.5
作者：
BAUMANN, K;MANDELKOW, EM;MANDELKOW, E
通讯作者：
MANDELKOW, E