KLRG1 restricts memory T cell antitumor immunity.
KLRG1 restricts memory T cell antitumor immunity.
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KLRG1限制记忆T细胞抗肿瘤免疫
DOI：
10.18632/oncotarget.11430
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发表时间：
2016-09-20
期刊：
影响因子：
--
通讯作者：
Zhao E
中科院分区：
文献类型：
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作者：
Li L;Wan S;Tao K;Wang G;Zhao E
杀伤细胞凝集素样受体亚家族G成员1（KLRG 1）已在人类记忆T淋巴细胞上发现。然而，KLRG 1对人类T细胞，特别是在肿瘤微环境中的作用尚未完全了解。我们的研究结果表明，在肿瘤微环境中，T细胞上的KLRG 1表达显著增加。KLRG 1 + T细胞增殖能力差，效应细胞因子产生减少。同时，KLRG 1 + T细胞表达丰富的促炎细胞因子，并表现出高水平的Foxp 3表达。KLRG 1 + T细胞显示miRNA-101表达降低和CtBP 2表达升高。提示KLRG 1可能参与了肿瘤微环境中记忆T细胞抗肿瘤免疫功能的受损。因此，抑制人类记忆T细胞上的KLRG 1可能是一种新的抗癌疗法。
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) has been found on human memory T lymphocytes. However, the roles of KLRG1 on human T cells especially in tumor microenvironment have not been fully understood. Our results showed KLRG1 expression on T cells significantly increased in tumor microenvironment. KLRG1+ T cells exhibited poor proliferative capacity with decreased effector cytokine production. Meanwhile, KLRG1+ T cells expressed abundant pro-inflammatory cytokines and demonstrated high level of Foxp3 expression. KLRG1+ T cells showed decreased expression of miRNA-101 and higher expression of CtBP2. Our results indicated KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment. Thus, repressing KLRG1 on human memory T cells might be a novel therapeutics against cancer.