Thermodynamic nucleic base specificity in nucleotide-metallointercalator association. Structure-stability relationship showing significant contribution of the amino group to aromatic ring stacking
Thermodynamic nucleic base specificity in nucleotide-metallointercalator association. Structure-stability relationship showing significant contribution of the amino group to aromatic ring stacking
复制标题
核苷酸-金属嵌入剂关联中的热力学核酸碱基特异性。
DOI：
10.1021/ic00024a003
复制
发表时间：
1991
影响因子：
4.6
通讯作者：
S. Ishiguro
中科院分区：
文献类型：
--
作者：
A. Odani;H. Masuda;O. Yamauchi;S. Ishiguro
平面化合物插入 DNA 碱基对极大地影响 DNA 的特性，被认为是诱变的第一步。 1 铂 (II) 和其他具有杂芳环 (L) 的金属络合物（例如 bpy 和 phen）通过与碱基对的堆积相互作用与 DNA 和核苷酸相互作用。 2· 3 Pt (II) 复合物的正电荷可能有助于通过与 DNA 磷酸氧的初始静电键合进行嵌入。 4 我们之前对铂 (II) 嵌入剂 Pt (L)(en)(L= bpy, phen,
Intercalation of planar compounds into base pairs of DNA greatly influences the properties of DNA and is thought to be the first step in mutagenesis. 1 Platinum (II) and other metal complexes with heteroaromatic rings (L) such as bpy and phen interact with DNA and nucleotides by stacking interactionswith the base pairs. 2· 3 The positive charge of the Pt (II) complexes probably contribute to intercalation through the initial electrostatic bonding with the phosphate oxygens of DNA. 4 Our previous circular dichroism (CD) and NMR spectral studies on the intercalation of the platinum (II) intercalators Pt (L)(en)(L= bpy, phen,