Subthreshold and suboptimal desensitization of human basophils. II. Nonspecificity and irreversibility of desensitization.
Subthreshold and suboptimal desensitization of human basophils. II. Nonspecificity and irreversibility of desensitization.
复制标题
人类嗜碱性粒细胞的阈下和次优脱敏。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
K. Minagawa
中科院分区：
文献类型：
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作者：
G. Mendoza;K. Minagawa
在正常钙缓冲液条件下，次优水平的抗人IgE或抗原诱导人嗜碱性粒细胞脱敏。低剂量的抗IgE在3小时的预孵育期间仅触发0-12%的组胺释放，但在再激发时启动高达100%的脱敏。在与过敏原a预孵育24-27小时后，当用过敏原a、过敏原B或抗IgE再激发时，细胞没有恢复可释放性。低剂量IgE介导的人嗜碱性粒细胞脱敏可能导致不可逆和非特异性的脱粒抑制。
Desensitization in human basophils was induced by suboptimal levels of antihuman IgE or antigen under normal calcium buffer conditions. Low doses of anti-IgE triggered only 0-12% histamine release during a 3-hour preincubation, yet initiated up to 100% desensitization upon rechallenge. After 24-27 h preincubation with allergen a, the cells did not regain releasability when rechallenged with either allergen a, allergen b or anti-IgE. Low dose, IgE-mediated desensitization in human basophils may lead to an irreversible and nonspecific inhibition of degranulation.