DIAGNOSTIC-TESTS IN PATIENTS WITH SYMPTOMS OF KERATOCONJUNCTIVITIS SICCA
DIAGNOSTIC-TESTS IN PATIENTS WITH SYMPTOMS OF KERATOCONJUNCTIVITIS SICCA
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DOI：
10.1016/0002-9394(88)90587-9
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发表时间：
1988-11-15
影响因子：
4.2
通讯作者：
GOREN, SB
中科院分区：
文献类型：
--
作者：
GOREN, MB;GOREN, SB
我们比较了泪膜破裂时间的相对值，Schirmer试验，乳铁蛋白免疫测定，并在156例不同严重程度的干燥性角结膜炎的症状特征和39个对照组的玫瑰红染色。统计学分析表明，在最小眼刺激的患者中，Schirmer试验结合乳铁蛋白免疫测定提供了高试验灵敏度和低假阳性率之间的最佳平衡。在具有中度至重度眼烧灼感、异物感或疼痛但没有口干或关节炎的全身症状的患者中，以及在具有眼和全身主诉的患者中，单独的乳铁蛋白测定提供了统计学显著的结果。泪膜破裂时间和虎红染色没有用，Schirmer试验在测量这些患者的泪液分泌率方面价值有限。
We compared the relative value of the tear film breakup time, Schirmer test, lactoferrin immunologic assay, and rose bengal staining in 156 patients with varying severity of symptoms characteristic of keratoconjunctivitis sicca and in 39 controls. Statistical analysis showed that in patients with minimal ocular irritation the Schirmer test in combination with the lactoferrin immunologic assay provided an optimal balance between high test sensitivity and low false-positive rates. In patients with moderate to severe ocular burning, foreign body sensation, or pain but with no systemic symptoms of dry mouth or arthritis, and in patients with both ocular and systemic complaints, the lactoferrin assay alone provided statistically significant results. Tear film breakup time and staining with rose bengal were not useful and the Schirmer test had limited value in measuring the rate of tear secretion in these patients.