Invasive central nervous system aspergillosis in a patient with Crohn's disease after treatment with infliximab and corticosteroids
Invasive central nervous system aspergillosis in a patient with Crohn's disease after treatment with infliximab and corticosteroids
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DOI：
10.1016/j.jocn.2016.02.009
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发表时间：
2016-08-01
影响因子：
2
通讯作者：
Dimou, James
中科院分区：
文献类型：
--
作者：
Bourne, Emma-Lee;Dimou, James
曲霉菌正在成为免疫受损宿主肺炎死亡的重要原因，血液学传播是一种罕见的威胁生命的并发症。中枢神经系统(CNS)作为肺外扩散的部位更为罕见。我们报告了一例中枢神经系统播散性曲霉菌病，患者接受了皮质类固醇和英夫利昔单抗治疗，英夫利昔单抗是一种免疫调节剂，通常用于炎症性肠病的治疗，并回顾了有关这种罕见病理的现有文献。皇冠版权所有(C)2016由爱思唯尔有限公司出版。保留所有权利。
Aspergillus species are emerging as a significant cause of pneumonia mortality in immune compromised hosts, with haematological spread being a rare and life-threatening complication. The central nervous system (CNS) as a site for extrapulmonary spread is rarer still. We report a case of CNS disseminated aspergillosis in a patient treated with corticosteroids and infliximab, an immunomodulatory agent commonly used in the treatment of inflammatory bowel disease, and review the available literature regarding this rare pathology. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.