The synergistic effects of traditional Chinese herbs and radiotherapy for cancer treatment.
The synergistic effects of traditional Chinese herbs and radiotherapy for cancer treatment.
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DOI：
10.3892/ol.2013.1245
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发表时间：
2013-05
期刊：
影响因子：
2.9
通讯作者：
Fan F
中科院分区：
文献类型：
--
作者：
Jia L;Ma S;Hou X;Wang X;Qased AB;Sun X;Liang N;Li H;Yi H;Kong D;Liu X;Fan F
传统中药对某些恶性肿瘤具有较强的细胞毒活性。电离辐射（IR）是临床治疗癌症最有效的方法之一。单一配方的缺点是它限制了癌症的治疗效果，而综合策略需要额外的理论支持。然而，不同抗肿瘤治疗方式的组合有利于限制在极高剂量的单一方案中经常观察到的非特异性毒性。凋亡性细胞死亡的诱导是放疗或化疗后肿瘤细胞中的重要过程，并且对这些治疗的抗性与低凋亡倾向有关。自噬是癌细胞对IR或化疗的反应，并且涉及细胞质中自噬空泡的显著形成。本文综述了中医药与放射治疗的协同作用及其机制，为肿瘤的治疗提供新的思路。
Traditional Chinese medicine (TCM) has been demonstrated to have potent cytotoxic activity against certain malignant tumors. Ionizing radiation (IR) is one of the most effective methods used in the clinical treatment of cancer. The drawback of a single formula is that it limits the treatment efficacy for cancer, while comprehensive strategies require additional theoretical support. However, a combination of different antitumor treatment modalities is advantageous in restricting the non-specific toxicity often observed with an extremely high dose of a single regimen. The induction of apoptotic cell death is a significant process in tumor cells following radiotherapy or chemotherapy, and resistance to these treatments has been linked to a low propensity for apoptosis. Autophagy is a response of cancer cells to IR or chemotherapy, and involves the prominent formation of autophagic vacuoles in the cytoplasm. In this review, the synergistic effects of TCM and radiotherapy are summarized and the underlying mechanisms are illustrated, providing new therapeutic strategies for cancer.
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