Integration of White Matter Network Is Associated with Interindividual Differences in Psychologically Mediated Placebo Response in Migraine Patients
Integration of White Matter Network Is Associated with Interindividual Differences in Psychologically Mediated Placebo Response in Migraine Patients
复制标题
白质网络的整合与偏头痛患者心理介导的安慰剂反应的个体差异相关。
DOI：
10.1002/hbm.23729
复制
发表时间：
2017-10-01
影响因子：
4.8
通讯作者：
Zhang, Ming
中科院分区：
文献类型：
--
作者：
Liu, Jixin;Ma, Shaohui;Zhang, Ming
偏头痛反复发作和生理或心理应激时，人脑网络模块结构中神经通讯和整合的脑变化存在个体差异。然而，偏头痛脑连接体的个体间变异性是否能预测安慰剂对安慰剂治疗的反应仍不清楚。利用DTI和图论方法，我们系统地研究了白色网络的拓扑组织在71例偏头痛无先兆（MO）和50名匹配的健康对照在三个层次：全球网络测量，节点效率，节点模块内/模块间的效率。所有患者均接受为期8周的假针灸治疗以诱导镇痛。在我们的研究结果中，30%（n = 21）的患者在安慰剂治疗后偏头痛天数较基线变化50%。在基线时，与HC组相比，MO患者中发现网络整合异常增加，并且开始临床治疗前的总体效率增加与其随后的安慰剂应答相关。对于节点效率，患者白色物质网络中海马和额中回的子网络内节点效率和子网络间连通性的显著增加与随访安慰剂治疗的反应相关。我们的研究结果表明，疼痛相关的适应不良压力的特质样个体差异干扰和减少慢性疼痛调制的能力不同，和治疗的安慰剂反应可以预测从以前的白色物质网络模块化结构偏头痛。(C)2017年威利期刊公司
Individual differences of brain changes of neural communication and integration in the modular architecture of the human brain network exist for the repeated migraine attack and physical or psychological stressors. However, whether the interindividual variability in the migraine brain connectome predicts placebo response to placebo treatment is still unclear. Using DTI and graph theory approaches, we systematically investigated the topological organization of white matter networks in 71 patients with migraine without aura (MO) and 50 matched healthy controls at three levels: global network measure, nodal efficiency, and nodal intramodule/intermodule efficiency. All patients participated in an 8-week sham acupuncture treatment to induce analgesia. In our results, 30% (n = 21) of patients had 50% change in migraine days from baseline after placebo treatment. At baseline, abnormal increased network integration was found in MO patients as compared with the HC group, and the increased global efficiency before starting clinical treatment was associated with their following placebo response. For nodal efficiency, significantly increased within-subnetwork nodal efficiency and intersubnetwork connectivity of the hippocampus and middle frontal gyrus in patients' white matter network were correlated with the responses of follow-up placebo treatment. Our findings suggested that the trait-like individual differences in pain-related maladaptive stress interfered with and diminished the capacity of chronic pain modulation differently, and the placebo response for treatment could be predicted from a prior white matter network modular structure in migraineurs. (C) 2017 Wiley Periodicals, Inc.