Uncertainty in particulate deposition for 1 μm AMAD particles in an adult lung model
Uncertainty in particulate deposition for 1 μm AMAD particles in an adult lung model
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DOI：
10.1093/oxfordjournals.rpd.a006547
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发表时间：
2001-01-01
影响因子：
1
通讯作者：
Hamby, DM
中科院分区：
文献类型：
--
作者：
Harvey, RP;Hamby, DM
ICRP66肺模型可用于通过吸入途径确定公众成员的剂量估算。内部剂量学模拟中的一个重要不确定性来源是呼吸道区域的颗粒沉积。由于模型输入参数有其固有的可变性，因此在颗粒沉积估计中存在不确定性。为了更好地了解模型过程和更好地估计通过吸入途径暴露的个人所接受的剂量，需要对这些不确定因素进行审查。更好地理解颗粒沉积中的不确定性将进一步指导研究工作，并提高我们量化内部剂量估计的能力。当公众吸入AMAD颗粒时，ICRP66肺沉积模型对呼吸频率最敏感。沉积分数的不确定性跨越数量级，其分布因特定肺部区域的性别不同而不同。最大的部分沉积发生在深肺泡和胸外区域。
The ICRP 66 lung model may be used to determine dose estimates for members of the public via the inhalation pathway. A significant source of uncertainty in internal dosimetric modelling is due to particulate deposition in regions of the respiratory tract. Uncertainties in estimates of particulate deposition are present because model input parameters have their own inherent variability. These sources of uncertainty need to be examined in an effort to understand better model processes and to estimate better the doses received by individuals exposed through the inhalation pathway. An improved understanding of the uncertainty in particulate deposition will further guide research efforts and improve our ability to quantify internal dose estimates. The ICRP 66 lung deposition model is most sensitive to breathing rate when I mum AMAD particles are inhaled by members of the public. Uncertainties in deposition fractions are shown to span an order of magnitude with their distributions varying by gender for a particular lung region. The largest fractional deposition occurs in the deep lung alveolar and extrathoracic regions.