Localization of human frontal eye fields:: anatomical and functional findings of functional magnetic resonance imaging and intracerebral electrical stimulation
Localization of human frontal eye fields:: anatomical and functional findings of functional magnetic resonance imaging and intracerebral electrical stimulation
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DOI：
10.3171/jns.2001.95.5.0804
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发表时间：
2001-11-01
影响因子：
4.1
通讯作者：
Berthoz, A
中科院分区：
文献类型：
--
作者：
Lobel, E;Kahane, P;Berthoz, A
Object.本研究的目的是通过比较两项独立研究的结果，探讨人类额叶眼野（FEF）的解剖定位和功能作用。在第一项研究中，14名健康志愿者分为两组进行了3特斯拉功能性磁共振（fMR）成像：第一组在完全黑暗中执行自定步调的自愿扫视，第二组重复新学习或熟悉的扫视序列。在第二项研究中，在手术前对38名癫痫患者进行脑内电刺激（IES），并确定了刺激诱导versive眼球运动的额叶区域。这些研究表明，两个不同的眼区（OMAs）可以个性化的区域经典对应的FEF。一个OMA始终位于上级额沟与中央前沟上级部分底部的交叉处，并且是最容易通过电刺激引起扫视运动的OMA。第二个OMA位于更外侧，靠近中央前回表面。fMR成像研究和DES研究表明，在识别这些皮质区域时，解剖学和立体定向一致。这些研究结果表明，通过测量血管信号的帮助下，3特斯拉的fMR成像和神经成像和电生理记录可以一起使用，以获得更好地了解人类皮层功能解剖的皮层区域的infracentimetric本地化。
Object. The goal of this study was to investigate the anatomical localization and functional role of human frontal eye fields (FEFs) by comparing findings from two independently conducted studies.Methods. In the first study, 3-tesla functional magnetic resonance (fMR) imaging was performed in 14 healthy volunteers divided into two groups: the first group executed self-paced voluntary saccades in complete darkness and the second group repeated newly learned or familiar sequences of saccades. In the second study, intracerebral electrical stimulation (IES) was performed in 38 patients with epilepsy prior to surgery, and frontal regions where stimulation induced versive eye movements were identified. These studies showed that two distinct oculomotor areas (OMAs) could be individualized in the region classically corresponding to the FEFs. One OMA was consistently located at the intersection of the superior frontal sulcus with the fundus of the superior portion of the precentral sulcus, and was the OMA in which saccadic eve movements could be the most easily elicited by electrical stimulation. The second OMA was located more laterally, close to the surface of the precentral gyrus. The fMR imaging study and the DES study demonstrated anatomical ana stereotactic agreement in the identification of these cortical areas.Conclusions. These findings indicate that infracentimetric localization of cortical areas can be achieved by measuring the vascular signal with the aid of 3-tesla fMR imaging and that neuroimaging and electrophysiological recording can be used together to obtain a better understanding of the human cortical functional anatomy.