Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.

Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.
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DOI:
10.2217/fmb.09.133
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发表时间:
2010-03
影响因子:
3.1
通讯作者:
Carbonetti NH
Carbonetti NH
中科院分区:
生物学3区
文献类型:
--
作者:
Carbonetti NH

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百日咳毒素和腺苷酸环化酶毒素是百日咳杆菌的两个重要毒力因子,百日咳杆菌是引起呼吸道疾病百日咳或百日咳的细菌。除了对这两种毒素的结构、功能和发病机理的作用进行研究之外,由于它们能够进入哺乳动物细胞、进行酶活性和改变细胞信号事件,它们都被用作各种应用的细胞生物学工具。在这篇文章中,最近的数据从研究文献,提高我们的理解这两种毒素的性质,其作用的发病机制B。百日咳感染和疾病,特别是在调节宿主免疫反应,以及它们作为其他研究领域的工具的用途将被概述。
Pertussis toxin and adenylate cyclase toxin are two important virulence factors of Bordetella pertussis, the bacterial cause of the respiratory disease pertussis or whooping cough. In addition to studies on the structure, function and role in pathogenesis of these two toxins, they are both used as cell biology tools for a variety of applications owing to their ability to enter mammalian cells, perform enzymatic activities and modify cell signaling events. In this article, recent data from the research literature that enhance our understanding of the nature of these two toxins, their role in the pathogenesis of B. pertussis infection and disease, particularly in modulating host immune responses, and their use as tools for other areas of research will be outlined.
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