Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis.
Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis.
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DOI：
10.1002/art.40359
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Scher JU
中科院分区：
文献类型：
--
作者：
Manasson J;Shen N;Garcia Ferrer HR;Ubeda C;Iraheta I;Heguy A;Von Feldt JM;Espinoza LR;Garcia Kutzbach A;Segal LN;Ogdie A;Clemente JC;Scher JU
反应性关节炎（ReA）是一种在胃肠道或泌尿生殖道感染后数周发生的炎症性疾病。HLA-B27阳性被认为是一个危险因素，但不一定预测疾病的发病率。在非遗传因素中，肠道微生物组可能在疾病易感性中发挥作用。本研究的目的是表征肠道菌群和宿主基因在ReA和感染后脊柱关节炎中的相互作用。从一个高度流行的地理区域前瞻性招募成人外周脊柱关节炎和对照组受试者，这些受试者先前有感染，但没有发生关节炎。分析了临床变量、HLA状态和肠道菌群的16 S rRNA基因测序。ReA受试者在肠道细菌丰富度或多样性方面与对照组没有显着差异。然而，有一个显着较高的丰度欧文氏菌和假单胞菌，并增加了与ReA相关的典型肠道病原体的患病率。附着点炎的超声证据的主题是丰富的弯曲杆菌，而葡萄膜炎和放射性骶髂关节炎的主题分别丰富欧文氏菌和未分类的瘤胃球菌科，都丰富的小杆菌。宿主遗传学，特别是HLA-A24，与肠道微生物群多样性的差异有关，而与疾病状态无关。我们确定了几个共同出现的分类群，也预测HLA-A24状态。这是第一个独立于培养的研究，描述了感染后关节炎的肠道微生物群落。虽然细菌因素与疾病的存在和ReA的临床特征相关，但宿主遗传学似乎也是肠道群落组成的主要独立驱动因素。了解这些肠道微生物群宿主遗传关系可能会进一步阐明感染后脊柱关节病的发病机制。
Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary infections. HLA-B27 positivity is considered a risk factor, though not necessarily predictive of disease incidence. Among non-genetic factors, the intestinal microbiome may play a role in disease susceptibility. The objective of this study was to characterize the gut microbiota and host gene interactions in ReA and post-infectious spondyloarthritis. Adult peripheral spondyloarthritis and control subjects with preceding infections that did not develop arthritis were prospectively recruited from a highly prevalent geographic region. Clinical variables, HLA status, and 16S rRNA gene sequencing of intestinal microbiota were analyzed. ReA subjects showed no significant differences from controls in gut bacterial richness or diversity. However, there was a significantly higher abundance of Erwinia and Pseudomonas, and increased prevalence of typical enteropathogens associated with ReA. Subjects with ultrasound evidence of enthesitis were enriched in Campylobacter, while subjects with uveitis and radiographic sacroiliitis were respectively enriched in Erwinia and unclassified Ruminococcaceae, and both enriched in Dialister. Host genetics, particularly HLA-A24, were associated with differences in gut microbiota diversity irrespective of disease status. We determined several co-occurring taxa that were also predictive of HLA-A24 status. This is the first culture-independent study characterizing the gut microbial community of post-infectious arthritis. Although bacterial factors correlated with disease presence and clinical features of ReA, host genetics also appeared to be a major independent driver of intestinal community composition. Understanding of these gut microbiota host-genetic relationships may further clarify the pathogenesis of post-infectious spondyloarthropathies.
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影响因子：
3.7
作者：
Gomez A;Luckey D;Yeoman CJ;Marietta EV;Berg Miller ME;Murray JA;White BA;Taneja V
通讯作者：
Taneja V
影响因子：
15.9
作者：
Abdollahi-Roodsaz, Shahla;Joosten, Leo A. B.;Van den Berg, Wim B.
通讯作者：
Van den Berg, Wim B.
影响因子：
2.7
作者：
de Juan, MD;Reta, A;Cuadrado, E
通讯作者：
Cuadrado, E
DOI：
10.1002/art.39681
发表时间：
2016-09
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Asquith MJ;Stauffer P;Davin S;Mitchell C;Lin P;Rosenbaum JT
通讯作者：
Rosenbaum JT
影响因子：
168.9
作者：
BREWERTON, DA;NICHOLLS, A;JAMES, DCO
通讯作者：
JAMES, DCO