Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives
Cellulose/chitosan hybrid nanofibers from electrospinning of their ester derivatives
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DOI：
10.1007/s10570-008-9266-9
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Hsieh, You-Lo
中科院分区：
文献类型：
--
作者：
Du, Jian;Hsieh, You-Lo
采用静电纺丝法制备了纤维素/壳聚糖杂化纳米纤维，并将其酯衍生物醋酸纤维素（CA）和二丁酰甲壳素（DBC）进行碱水解制备了纤维素（Cell）和壳聚糖（CS）。以甲壳素（CHI）和丁酸酐为原料，通过酸催化酰化反应合成了DBC，并通过红外光谱和核磁共振氢谱对产物的结构进行了表征。DBC在丙酮、DMAc、DMF、乙醇和乙酸中具有稳健的溶解度，除乙醇外的所有溶剂也是CA的溶剂，允许这些酯衍生物的混合。研究了DBC或CA单独和一起在这些常见溶剂及其混合物中通过静电纺丝形成纤维。发现1/1丙酮/乙酸是从DBC或CA以及它们的混合物在所有CA/DBC比率下生成纤维的最佳溶剂系统，导致直径范围为30至350 nm的杂化纤维。DBC和CA混合良好，在混杂纤维中没有显示相分离。等质量CA/DBC纳米纤维的碱性水解（NaOH）容易地通过O-脱酰化再生Cell和CHI，然后在较高的碱性浓度和/或温度下通过N-脱乙酰化进一步将CHI脱乙酰化为CS。在所研究的条件下，用5 N NaOH在100 A度C下水解3 h是再生纤维素/壳聚糖杂化纳米纤维的最佳条件。
A facile approach has been established to generate cellulose/chitosan hybrid nanofibers with full range of compositions by electrospinning of their ester derivatives, cellulose acetate (CA) and dibutyryl chitin (DBC), followed by alkaline hydrolysis to cellulose (Cell) and chitosan (CS). DBC was synthesized by acid-catalyzed acylation of chitin (CHI) with butyric anhydride and the newly formed butyl groups on C3 and C6 were confirmed by FT-IR and (HNMR)-H-1. DBC had robust solubility in acetone, DMAc, DMF, ethanol, and acetic acid, all except ethanol were also solvents for CA, allowing mixing of these ester derivatives. Fiber formation by electrospinning of either DBC or CA alone and together in these common solvents and their mixtures were studied. The 1/1 acetone/acetic acid was found to be the optimal solvent system to generate fibers from either DBC or CA as well as their mixtures at all CA/DBC ratios, resulting in hybrid fibers with diameters ranging from 30 to 350 nm. DBC and CA were well mixed and showed no phase separate in the hybrid fibers. Alkaline hydrolysis (NaOH) of the equal mass CA/DBC nanofibers regenerated Cell and CHI readily via O-deacylation, then proceeded to further deacetylate CHI to CS via N-deacetylation at higher alkaline concentrations and/or temperatures. Under conditions studied, hydrolysis with 5N NaOH at 100 A degrees C for 3 h was optimal to regenerate cellulose/chitosan hybrid nanofibers.