HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY
HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY
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DOI：
10.1126/science.7824947
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发表时间：
1995-01-27
期刊：
影响因子：
56.9
通讯作者：
COFFIN, JM
中科院分区：
文献类型：
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作者：
COFFIN, JM
最近的几份报告表明，人类免疫缺陷病毒（HIV）感染的长期临床潜伏期并不是病毒不活动的时期，而是一个活跃的过程，在这个过程中，细胞被感染并以高速度大量死亡。这些结果导致了一个简单的稳态模型，其中感染，细胞死亡和细胞替换处于平衡状态，并暗示HIV的独特特征是在单个个体感染期间发生的非常大量的复制周期。这种周转驱动致病过程和（甚至超过突变率）遗传变异的发展。这种变异包括不可避免的和原则上可预测的突变积累，例如那些赋予抗病毒药物抗性的突变，在设计治疗策略时必须考虑这些突变在治疗前的存在，
Several recent reports indicate that the long, clinically latent phase that characterizes human immunodeficiency virus (HIV) infection of humans is not a period of viral inactivity, but an active process in which cells are being infected and dying at a high rate and in large numbers. These results lead to a simple steady-state model in which infection, cell death, and cell replacement are in balance, and imply that the unique feature of HIV is the extraordinarily large number of replication cycles that occur during infection of a single individual. This turnover drives both the pathogenic process and (even more than mutation rate) the development of genetic variation. This variation includes the inevitable and, in principle, predictable accumulation of mutations such as those conferring resistance to antiviral drugs whose presence before therapy must be considered in the design of therapeutic strategies,