The difficulty of targeting cancer stem cell niches.
The difficulty of targeting cancer stem cell niches.
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DOI：
10.1158/1078-0432.ccr-09-2933
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发表时间：
2010-06-15
期刊：
影响因子：
--
通讯作者：
LaBarge MA
中科院分区：
文献类型：
--
作者：
LaBarge MA
正常干细胞龛通常通过其独特的解剖特征和与组织特异性干细胞的关联来识别。确定癌症干细胞（CSC）壁龛是一个特殊的问题，因为肿瘤之间几乎没有共同的解剖特征，而且据报道，将CSC描述为实体的物理表型可能受宿主微环境、性别和肿瘤分期的影响。不管生态位的位置、占位者的表型或精确的分子组成如何，所有的生态位都必须做一件基本相同的事情：维持干细胞中定义它的活动。因此，一个潜在的成功策略，无论是对CSC生态位的分子和细胞描绘，还是对它们的治疗靶向，都是在肿瘤微环境中识别出在面对细胞毒性治疗方案时维持自我更新、分化和静止功能所需的成分。
Normal stem cell niches typically are identified by their distinctive anatomical features and by association with tissue-specific stem cells. Identifying cancer stem cell (CSC) niches presents a special problem because there are few if any common anatomical features among tumors, and the physical phenotypes that reportedly describe the CSCs as entities may be subject to the host's microenvironment, sex, and tumor stage. Irrespective of a niche's location, the occupant's phenotype, or the precise molecular composition, all niches must do basically the same thing: maintain the activities in a stem cell that define it as such. Therefore, a potentially successful strategy, both for elaborating a molecular and cellular portrait of a CSC niche, and for therapeutically targeting them, is to identify components in the tumor microenvironment that are required for maintaining the functions of self-renewal, differentiation, and quiescence in the face of cytotoxic therapeutic regimens.