Maternal obesity, gestational diabetes, breastfeeding and childhood overweight at age 2 years
Maternal obesity, gestational diabetes, breastfeeding and childhood overweight at age 2 years
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DOI：
10.1111/ijpo.12125
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发表时间：
2017-04-01
影响因子：
3.8
通讯作者：
Xiang, A. H.
中科院分区：
文献类型：
--
作者：
Bider-Canfield, Z.;Martinez, M. P.;Xiang, A. H.
BackgroundMaternal obesity，excessive gestational weight gain（EGWG），gestational diabetes mellitus（GDM）and breathing are four important factors associated with children obesity.ObjectivesThe objective of the study was to assess the interplay among these factors and their independent contributions to children overweight in a cohort with standard clinical care.MethodsThe cohort included 15710 mother-children pairs delivered in 2011.结果孕前肥胖或超重的母亲更容易患EGWG和GDM，且母乳喂养6个月的可能性更小。与非GDM母亲相比，GDM母亲的EGWG率低40-49%，母乳喂养率相似。调整暴露和协变量后的分析显示，（95%置信区间）与2岁时儿童期超重相关性为2.34（2.09-2.62）、1.50（1.34-1.68）、1.23（1.12-1.35）、0.95（0.83-1.10）和0.76（0.69-0.83）。
BackgroundMaternal obesity, excessive gestational weight gain (EGWG), gestational diabetes mellitus (GDM) and breastfeeding are four important factors associated with childhood obesity.ObjectivesThe objective of the study was to assess the interplay among these four factors and their independent contributions to childhood overweight in a cohort with standard clinical care.MethodsThe cohort included 15710 mother-offspring pairs delivered in 2011. Logistic regression was used to assess associations between maternal exposures and childhood overweight (body mass index >85th percentile) at age 2years.ResultsMothers with pre-pregnancy obesity or overweight were more likely to have EGWG, GDM and less likely to breastfeed 6months. Mothers with GDM had 40-49% lower EGWG rates and similar breastfeeding rates compared with mothers without GDM. Analysis adjusted for exposures and covariates revealed an adjusted odds ratio (95% confidence interval) associated with childhood overweight at age 2years of 2.34 (2.09-2.62), 1.50 (1.34-1.68), 1.23 (1.12-1.35), 0.95 (0.83-1.10) and 0.76 (0.69-0.83) for maternal obesity, overweight, EGWG, GDM and breastfeeding 6months vs.