Chemical constituents of Lobelia chinensis
Chemical constituents of Lobelia chinensis
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半边莲的化学成分
DOI：
10.1016/j.fitote.2014.01.007
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发表时间：
2014-03-01
期刊：
影响因子：
3.4
通讯作者：
Ren, Dongmei
中科院分区：
文献类型：
--
作者：
Yang, Shuang;Shen, Tao;Ren, Dongmei
从半边莲全草中分得三个新的2，6-二取代哌啶生物碱（1-3），一个新的聚乙炔（8），以及八个已知化合物（4-7，9-12）。根据光谱数据解析了它们的结构。1的绝对构型是通过一个方便的Mosher酯程序确定的，在该程序中，样品直接在NMR管中用MTPA氯化物在氘代吡啶中处理。针对两种人肺癌细胞系NCI-H292和MSTO-211 H测试化合物1-12的细胞毒性。化合物8和9对两种癌细胞系显示出中等的细胞毒活性，IC 50值在9.31-12.36 μ M的范围内。(C)2014爱思唯尔有限公司版权所有。
Three new 2, 6-disubstituted piperidine alkaloids (1-3), one new polyacetylene (8), together with eight known compounds (4-7, 9-12) were isolated from the whole plants of Lobelia chinensis. Their structures were elucidated on the basis of spectroscopic data interpretation. The absolute configuration of 1 was established by a convenient Mosher ester procedure in which the sample was treated with MTPA chlorides in deuterated pyridine directly in NMR tube. Cytotoxicities of compounds 1-12 were tested against two human lung cancer cell lines, NCI-H292 and MSTO-211H. Compounds 8 and 9 exhibited moderate cytotoxic activity against the two cancer cell lines with the IC50 values in the range of 9.31-12.36 mu M. (C) 2014 Elsevier B.V. All rights reserved.