The effect of colchicine on normal and neoplastic tissues in mice
The effect of colchicine on normal and neoplastic tissues in mice
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DOI：
10.1002/path.1700440220
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发表时间：
1937-11-01
期刊：
影响因子：
--
通讯作者：
Clearkin, PA
中科院分区：
文献类型：
--
作者：
Clearkin, PA
移植肉瘤S37在体内的生长不受移植前和移植后每隔一天给予秋水仙碱的抑制。从用秋水仙素处理的动物获得的移植物的生长速率略有滞后。尽管用秋水仙碱治疗，小鼠中已建立的肿瘤的生长仍是进行性的。从秋水仙素处理的动物获得的S37的体外生长被显著抑制。剖切处理后小鼠各脏器的组织学变化。注射1/2 M.L.D.描述了给予该量导致中期有丝分裂停滞、细胞死亡和破坏。这种作用仅限于细胞快速分裂的组织，但在小鼠肉瘤S37中，其程度低于许多非恶性组织。
Growth of trans-plantable sarcoma S37 in vivo is not inhibited by administration of colchicine before grafting and subsequently every alternate day after grafting. There is a slight lag in the rate of growth of grafts obtained from an animal treated with colchicine. Growth of established tumours in mice is progressive despite treatment with colchicine. Growth in vitro of S37 obtained from a colchicine treated animal is markedly inhibited. The histological changes in various organs of mice treated by subcut. injection of 1/2 M.L.D. are described. Administration of this quantity leads to arrest of mitosis in metaphase, death and destruction of the cell. This effect is confined to tissues in which rapid cell division is normally in progress; but in mouse sarcoma S37 it is less in degree than in many non-malignant tissues.