CIRCADIAN RHYTHMS OF PLASMA CORTICOID LEVELS INTRAOCULAR PRESSURE + AQUEOUS OUTFLOW FACILITY IN NORMAL + GLAUCOMATOUS EYES
CIRCADIAN RHYTHMS OF PLASMA CORTICOID LEVELS INTRAOCULAR PRESSURE + AQUEOUS OUTFLOW FACILITY IN NORMAL + GLAUCOMATOUS EYES
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DOI：
10.1111/j.1749-6632.1964.tb48212.x
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发表时间：
1964-01-01
期刊：
影响因子：
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通讯作者：
MCLEOD, LE
中科院分区：
文献类型：
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作者：
BOYD, TAS;MCLEOD, LE
青光眼患者血浆皮质醇水平的昼夜节律与眼压水平呈正相关，当眼压水平与4小时前的皮质醇水平配对时，相关性最好。用β-羟基酶抑制剂阻断血浆皮质醇的上升阶段之后，眼压的上升阶段也会中断，同样有4小时的延迟。这些发现提示青光眼患者眼压的昼夜波动与血浆皮质激素的昼夜波动有关，并可能由其决定。在正常眼和青光眼中，房水流出设施的昼夜节律与眼压呈负相关。这些发现提示，眼压可能是控制流出设施昼夜节律的主要因素。
The circadian rhythm of plasma corticoid and IOP [Intra-ocular pressure] levels are positively correlated in glaucoma, the best correlation occurring when IOP levels are paired with corticoid levels which had occurred 4 hours previously. Interruption of the rising phase of the plasma corticoids by a beta-hydroxylase inhibitor is followed by interruption of the rising phase of IOP, again with a 4-hour lag. These findings suggest that the circadian fluctuations of IOP in glaucoma are related to and perhaps determined by the circadian fluctuations of plasma corticoids. The circadian rhythm of aqueous outflow facility is inversely related to IOP in both normal and glaucomatous eyes. These findings suggest that IOP may be the main factor controlling the circadian rhythm of outflow facility.