The associations of birth outcome differences in twins with prenatal exposure to bisphenol A and its alternatives.
The associations of birth outcome differences in twins with prenatal exposure to bisphenol A and its alternatives.
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双胞胎出生结局差异与产前接触双酚 A 及其替代品的关联。
DOI：
10.1016/j.envres.2021.111459
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发表时间：
2021-06
影响因子：
8.3
通讯作者：
Yang Pan
中科院分区：
文献类型：
--
作者：
Wang Jie;Mei Hong;Zhou Ai-Fen;Huang Li-Li;Cao Zhong-Qiang;Hong Ao-Bo;Yang Meng;Xie Qi-Tong;Chen Da;Yang Shao-Ping;Xiao Han;Yang Pan
背景双酚A（BPA）及其替代物（包括BPF和BPS）具有内分泌干扰活性。然而，双酚对胎儿生长的影响在twin. Objectives探讨产前BPA，BPF和BPS暴露与出生结果的差异在twin.MethodsWe招募了289双胞胎孕妇谁访问了医院的产前检查在第一个三个月从2013年至2016年的关联。尿双酚水平测定在第一，第二和第三孕期。母亲接触双酚与双胞胎出生结局差异的关联在不同孕期分层后进行了分析。我们应用多信息模型来估计尿双酚浓度和双胞胎的出生结局差异之间的三个月特定的关联。ResultsWe发现母亲尿BPA和BPF和BPS的再现性低（ICC<0.40）和中等（0.40 < ICC<0.75）。当比较三个妊娠期的第三个与第一个三分位数时，尿BPA浓度与双胞胎出生体重差异呈正相关（即，妊娠早期、妊娠中期和妊娠晚期分别为133.06 g，95%CI：68.19，197.94; 144.5 g，95%CI：81.82-207.18 g;和135.04 g，95%CI：71.37-198.71 g）。不同孕期尿BPA浓度对双胞胎出生身长差异增加的影响也被观察到（所有P趋势< 0.05）。尿BPA水平与妊娠三个月内双胞胎的出生体重和出生身长差异呈正相关（所有3型P值< 0.05）。我们的结果需要进一步证实。
BackgroundBisphenol A (BPA) and its alternatives, including BPF and BPS, exhibit endocrine disruption activities. However, the effects of bisphenols on fetal growth in twins remain unclear.ObjectiveTo explore the associations of prenatal BPA, BPF, and BPS exposure with birth outcome differences in twins.MethodsWe recruited 289 twin pregnant women who visited the hospital for prenatal examination during the first trimester from 2013 to 2016. Urinary bisphenol levels were determined during the first, second, and third trimesters. The associations of maternal exposure to bisphenols with birth outcome differences in twins were analyzed after stratification by different trimesters. We applied the multiple informant model to estimate trimester-specific associations between urinary bisphenol concentrations and birth outcome differences in twins.ResultsWe found low reproducibility (ICC<0.40) for maternal urinary BPA and moderate reproducibility (0.40 < ICC<0.75) for BPF and BPS. Urinary BPA concentrations were positively associated with within-pair twin birth weight difference when comparing the third vs. the first tertile in each of the three trimesters (i.e., 133.06 g, 95% CI: 68.19, 197.94; 144.5 g, 95%CI: 81.82–207.18 g; and 135.04 g, 95%CI: 71.37–198.71 g for the 1st, 2nd, and 3rd trimester, respectively). The effect of urinary BPA concentration on increased birth length difference within-pair twins were also observed across different trimesters (All P for trends < 0.05). Urinary BPA levels were positively associated with the within-pair birth weight and birth length differences across pregnancy trimesters (All of Type 3 P for values < 0.05).ConclusionMaternal BPA exposure appeared to influence birth wight and birth length differences in twins. Our results warrant further confirmation.