Palladium-Catalyzed Direct Ethynylation of C(sp3)-H Bonds in Aliphatic Carboxylic Acid Derivatives
Palladium-Catalyzed Direct Ethynylation of C(sp3)-H Bonds in Aliphatic Carboxylic Acid Derivatives
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DOI：
10.1021/ja206002m
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发表时间：
2011-08-24
影响因子：
15
通讯作者：
Chatani, Naoto
中科院分区：
文献类型：
--
作者：
Ano, Yusuke;Tobisu, Mamoru;Chatani, Naoto
首次完成了未活化的C（sp（3））-H键的催化炔基化反应。该方法允许在钯催化下将乙炔基直接引入脂肪酸衍生物中。这种新的反应可以应用于复杂的脂肪酸的快速制备，例如，通过叠氮化物/炔环加成。
The first catalytic alkynylation of unactivated C(sp(3))-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition.