Joint association of coffee consumption and other factors to the risk of type 2 diabetes: a prospective study in Finland
Joint association of coffee consumption and other factors to the risk of type 2 diabetes: a prospective study in Finland
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DOI：
10.1038/sj.ijo.0803341
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发表时间：
2006-12-01
影响因子：
4.9
通讯作者：
Tuomilehto, J.
中科院分区：
文献类型：
--
作者：
Hu, G.;Jousilahti, P.;Tuomilehto, J.
目的：研究咖啡摄入量和其他因素（包括体力活动、肥胖和饮酒）与 2 型糖尿病风险的联合关联。设计：前瞻性随访研究。受试者：总共 10188 名芬兰男性和 11197 名年龄在 35-74 岁的女性，基线时没有中风、冠心病或糖尿病史。测量：一份关于咖啡、茶、酒精和其他食物消耗、体力活动、吸烟、社会经济因素和病史，以及使用标准化方案测量的身高、体重和血压。结果：在平均 13.4 年的随访期间，有 964 例 2 型糖尿病病例。多变量调整后（年龄、研究年份、收缩压、教育程度、吸烟、体力活动、体重指数（BMI）以及水果、蔬菜、香肠、面包、酒精和茶的摄入量），饮用 0-2、3-6 杯和 >= 7 杯咖啡的参与者患 2 型糖尿病的风险比分别为 1.00、0.77 和 0.66（趋势 P = 0.022），女性分别为 1.00、0.71 和 0.52（趋势 P = 0.001），男性和女性合计（也根据性别进行调整）分别为 1.00、0.75 和 0.61（趋势 P < 0.001）。这种负相关在体力活动和体重指数联合水平的受试者以及饮酒者和不饮酒者中都是一致的。在肥胖和缺乏运动的人群中，每天喝七杯或更多咖啡可以将 2 型糖尿病的风险降低一半。结论：无论男性还是女性，喝咖啡都可以降低 2 型糖尿病的风险，并且无论体力活动、BMI 和饮酒水平如何，都可以观察到这种关联。
Objective: To examine joint associations of coffee consumption and other factors ( including physical activity, obesity and alcohol consumption) with the risk of type 2 diabetes.Design: Prospective follow-up study.Subjects: In all, 10188 Finnish men and 11197 women aged 35-74 years without a history of stroke, coronary heart disease or diabetes at baseline.Measurement: A self-administered questionnaire data on coffee, tea, alcohol and other food consumption, physical activity, smoking, socio-economic factors and medical history, together with measured height, weight and blood pressure using standardized protocol.Results: During a mean follow-up of 13.4 years, there were 964 incident cases of type 2 diabetes. Multivariate-adjusted (age, study year, systolic blood pressure, education, smoking, physical activity, body mass index (BMI) and fruit, vegetable, sausage, bread, alcohol and tea consumption) hazard ratio of type 2 diabetes in participants who drank 0-2, 3-6 and >= 7 cups of coffee were 1.00, 0.77 and 0.66 (P = 0.022 for trend) in men, 1.00, 0.71 and 0.52 (P = 0.001 for trend) in women, and 1.00, 0.75 and 0.61 (P < 0.001 for trend) in men and women combined (adjusted also for sex), respectively. This inverse association was consistent in subjects with any joint levels of physical activity and BMI, and in alcohol drinkers and non-drinkers. Among obese and inactive people, coffee drinking of seven cups or more daily reduced the risk of type 2 diabetes to half.Conclusions: Coffee drinking was associated with a reduced risk of type 2 diabetes in both men and women, and this association was observed regardless of the levels of physical activity, BMI and alcohol consumption.