Proof of concept: Partner-Assisted Interpersonal Psychotherapy for perinatal depression
Proof of concept: Partner-Assisted Interpersonal Psychotherapy for perinatal depression
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DOI：
10.1007/s00737-012-0311-1
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发表时间：
2012-12-01
影响因子：
4.5
通讯作者：
Jarrett, Robin B.
中科院分区：
文献类型：
--
作者：
Brandon, Anna R.;Ceccotti, Nadia;Jarrett, Robin B.
尽管伴侣支持不佳是孕妇和产后妇女抑郁症的一个关键风险因素，但伴侣通常不参与心理教育以外的治疗。这项“概念验证”研究的目的是测试伴侣辅助人际心理治疗（PA-IPT）的安全性、可接受性和可行性，这种干预措施包括伴侣在整个治疗过程中的积极参与者。估计孕龄超过 12 周且产后不到 12 周的女性，如果符合 DSM-IV 重度抑郁症标准并报告中度症状严重程度（HAM-D-17 千分之一16），则受邀参加。公开试验包括八次急性期会议和为期 6 周的随访评估。十对夫妇完成了急性期治疗，九对进行了为期 6 周的随访评估。没有发生与研究相关的不良事件，也没有女性从摄入到第八节期间出现症状恶化。所有伴侣都参加了所有疗程，没有夫妇退出治疗，并且在研究结束时所有人都报告了积极的治疗满意度。在急性期治疗结束时，十名女性中的九名 (90%) 符合临床缓解标准 (HAM-D-17 = 9)，在 6 周随访评估中出现的九名女性中的八名 (89%) 符合症状恢复标准。在围产期将伴侣纳入重度抑郁症的治疗是安全、可接受且可行的，但需要在更大的人群中进行进一步测试以评估疗效。
Although poor partner support is a key risk factor for depression in pregnant and postpartum women, partners are not generally involved in treatment beyond psychoeducation. The aim of this "proof of concept" study was to test safety, acceptability, and feasibility of Partner-Assisted Interpersonal Psychotherapy (PA-IPT), an intervention that includes the partner as an active participant throughout treatment. Women more than 12 weeks estimated gestational age and less than 12 weeks postpartum were invited to participate if they fulfilled DSM-IV criteria for Major Depressive Disorder and reported moderate symptom severity (HAM-D-17 a parts per thousand yen16). The open trial included eight acute-phase sessions and a 6-week follow-up assessment. Ten couples completed the acute phase treatment and nine presented for a 6-week follow-up assessment. There were no study-related adverse events, and no women had symptomatic worsening from intake to Session Eight. All partners attended all sessions, no couples dropped out of treatment, and all reported positive treatment satisfaction at the conclusion of the study. Nine of ten women (90 %) met the criteria for clinical response (HAM-D-17 = 9) at the conclusion of acute phase treatment, and eight of the nine (89 %) presenting at a 6-week follow-up assessment met criteria for symptomatic recovery. Incorporating partners in the treatment of major depressive disorders during the perinatal period is safe, acceptable, and feasible, but needs further testing in a larger population to evaluate efficacy.