Immediate and delayed cord clamping in infants born between 24 and 32 weeks: a pilot randomized controlled trial.
Immediate and delayed cord clamping in infants born between 24 and 32 weeks: a pilot randomized controlled trial.
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DOI：
10.1038/sj.jp.7210970
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发表时间：
2003-09-01
期刊：
影响因子：
--
通讯作者：
Oh, William
中科院分区：
文献类型：
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作者：
Mercer, Judith S;McGrath, Margaret M;Oh, William
目的：这项试点研究的目的是建立一个协议的可行性延迟脐带钳（DCC）与立即脐带钳（ICC）在早产，并检查其对初始血压和其他outcomes. Study设计的影响：随机对照试验招募32名婴儿之间的24和32周。分娩前，母亲被随机分配到ICC（脐带夹紧在5至10秒）或DCC（30至45秒延迟脐带夹紧）groups.Results：意向治疗分析显示，DCC组更有可能有较高的初始平均血压（调整OR 3.4），不太可能出院的氧气（调整OR 8.6）。DCC组婴儿的初始血糖水平较高（ICC=36 mg/dl，DCC=73.1 mg/dl; p=0.02）。改善血压的直接益处得到了证实，其他发现值得考虑进一步研究。
OBJECTIVE: This pilot study's aim was to establish feasibility of a protocol for delayed cord clamping (DCC) versus immediate cord clamping (ICC) at preterm birth and to examine its effects on initial blood pressure and other outcomes.STUDY DESIGN: A randomized controlled trial recruited 32 infants between 24 and 32 weeks. Immediately before delivery, mothers were randomized to ICC (cord clamped at 5 to 10 seconds) or DCC (30- to 45-second delay in cord clamping) groups.RESULTS: Intention-to-treat analyses revealed that the DCC group were more likely to have higher initial mean blood pressures (adjusted OR 3.4) and less likely to be discharged on oxygen (adjusted OR 8.6). DCC group infants had higher initial glucose levels (ICC=36 mg/dl, DCC=73.1 mg/dl; p=0.02).CONCLUSION: The research design is feasible. The immediate benefit of improved blood pressure was confirmed and other findings deserve consideration for further study.