Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma
Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma
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DOI：
10.1111/j.1440-1746.2010.06559.x
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发表时间：
2011-04-01
影响因子：
4.1
通讯作者：
Koike, Kazuhiko
中科院分区：
文献类型：
--
作者：
Masuzaki, Ryota;Shiina, Shuichiro;Koike, Kazuhiko
背景和目的：超声造影（CEUS）中持续60分钟或更长时间的Sonazoid Kupffer成像可能在超声引导下经皮肿瘤消融中有用。Sonazoid在肝细胞癌（HCC）射频消融（RFA）中的实用性进行了调查，在这项研究中：方法：我们分析了共716 HCC结节，动态CT检测316例。比较CEUS和常规超声检查对这些结节的检出率。通过比较CEUS治疗患者的RFA平均治疗次数和与肿瘤和背景条件相匹配的历史对照组的RFA平均治疗次数来评估治疗效果。结果：常规超声对肿瘤结节的检出率为83.5%，CEUS为93.2%（P = 0.04）。52例患者的69个结节被CEUS额外检测到。肿瘤结节检出率与血清白蛋白水平呈正相关（P = 0.016）。使用CEUS的RFA次数为1.33 +/- 0.45，而历史对照组为1.49 +/- 0.76（P = 0.0019）。结论：使用Sonazoid的CEUS对于肝功能储存良好的患者的HCC检测很有用。RFA治疗次数的减少表明Sonazoid在HCC RFA治疗中的效用。
Background and Aims:Kupffer imaging in contrast-enhanced ultrasonography (CEUS) with Sonazoid, which lasts for 60 min or longer, may be useful in ultrasound-guided percutaneous tumor ablation. The utility of Sonazoid in radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) was investigated in this study.Methods:We analyzed a total of 716 HCC nodules that were detected on dynamic computed tomography in 316 patients. Detectability of these nodules was compared between CEUS and conventional ultrasonography. The effectiveness in the treatment was assessed by comparing the mean numbers of treatment sessions of RFA in patients treated with CEUS and that in historical controls matched for tumor and background conditions.Results:Detectability of tumor nodule was 83.5% in conventional ultrasonography and 93.2% in CEUS (P = 0.04). Sixty-nine nodules in 52 patients were additionally detected with CEUS. The number of additionally detected tumor nodules was positively correlated with serum albumin level (P = 0.016). The number of RFA sessions was 1.33 +/- 0.45 with CEUS as compared to 1.49 +/- 0.76 in the historical controls (P = 0.0019).Conclusions:CEUS with Sonazoid is useful for HCC detection in patients with a well-conserved liver function reservoir. The decrease in RFA session numbers indicated the utility of Sonazoid in RFA treatment of HCC.