Psychological and physiological responses to postprandial mental stress in women with the irritable bowel syndrome
Psychological and physiological responses to postprandial mental stress in women with the irritable bowel syndrome
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DOI：
10.1097/00006842-200109000-00014
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发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Orr, WC
中科院分区：
文献类型：
--
作者：
Elsenbruch, S;Lovallo, WR;Orr, WC
目的：探讨肠易激综合征(IBS)患者餐后心理应激的心理反应(情感反应和症状反应)和生理反应(自主神经反应和皮质醇反应)。假设IBS患者会对心理应激源表现出夸大的自主神经和皮质醇反应，应激源会增强胃肠道症状，方法：24名IBS女性和20名健康女性参与了为期两天的研究方案。这两天是相同的，除了有一天，一项有压力的精神任务是在摄入了一顿标准的食物后完成的。在应用应激源之前和之后测量心率变异性、皮质醇、情感反应和症状反应。结果：IBS患者在基线和对应激源的反应中表现出更多的负性情绪。胃肠道症状不受应激源的影响。IBS患者对应激源的评估与对照组没有不同。在对应激源的自主神经反应方面，没有组间差异。两组都没有对应激源的总体皮质醇反应。结论：IBS患者对餐后心理应激和单独进食有更大的负面影响，根据自我报告数据可以将他们与对照组区分开来。不能根据心理应激源后交感神经激活的变化模式来区分IBS患者和对照组，本研究中使用的应激源在两组中都没有引起皮质醇反应。
Objective: To investigate the psychological (affective and symptomatic) and physiological (autonomic and cortisol) responses to postprandial mental stress in women with irritable bowel syndrome (IBS). It was hypothesized that patients with IBS would show exaggerated autonomic and cortisol responses to the psychological stressor and that the stressor would enhance gastrointestinal symptoms, Method: Twenty-four women with IBS and 20 healthy women participated in the two-day study protocol. Both days were identical, with the exception that on one day, a stressful mental task was completed after ingestion of a standard meal. Heart rate variability, cortisol, affective, and symptomatic responses were measured before and after application of the stressor. Results: Patients with IBS demonstrated increased negative affect at baseline and in response to the stressor. Gastrointestinal symptoms were not affected by the stressor. Appraisal of the stressor by patients with IBS was not different from that of controls. There were no group differences in the autonomic response to the stressor. There was no overall cortisol response to the stressor in either group. Conclusions: Patients with IBS respond with greater negative affect to postprandial psychological stress as well as to food intake alone, and they can be distinguished from controls on the basis of self-report data. Patients with IBS cannot be differentiated from controls on the basis of the pattern of changes in sympathetic activation after the mental stressor, The stressor used in this study did not elicit a cortisol response in either group.