Functional MRI: a potential physiologic indicator for stroke rehabilitation interventions.
Functional MRI: a potential physiologic indicator for stroke rehabilitation interventions.
复制标题
功能 MRI：中风康复干预的潜在生理指标。
DOI：
10.1161/01.str.0000071140.00153.05
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发表时间：
2003
期刊：
影响因子：
8.3
通讯作者：
Dobkin,BruceH
中科院分区：
文献类型：
--
作者：
Dobkin,BruceH
背景与目的：本研究假设脑卒中部位和恢复水平影响脑卒中后运动系统组织。方法：对14例对照组和21例慢性脑卒中患者（右为对照组，康复侧为患者）食指轻拍时进行功能性MRI检查。结果：在功能性MRI上，右臂受累的脑卒中患者显示：(1)与对照组相比，对侧运动皮层的激活明显减弱；(2)与左臂受累患者相比，同侧（非卒中）运动前激活较小，对侧（卒中侧）感觉运动激活较大，尽管各组肌电图相似；(3)尽管两组之间的敲击力、频率、运动范围和肌电图相似，但完全康复者的对侧感觉运动皮层的腹侧激活量比部分康复者大2.7倍。辅助运动区激活与恢复水平无关。结论：脑卒中后，损伤部位和最终运动状态不同，皮质组织也不同。这些发现可能对中风后的治疗有启示。2003年;34: e23-e28。)
Background and Purpose—The present study hypothesized that side of stroke and level of recovery influence motor system organization after stroke.Methods—Functional MRI was performed on 14 control subjects and 21 patients with chronic stroke during index finger tapping (control subjects, right; patients, recovered side).Results—On functional MRI, stroke patients with right arm involvement showed (1) significantly smaller activation in contralateral motor cortexes compared with control subjects;(2) smaller ipsilateral (nonstroke) premotor and larger contralateral (stroke-side) sensorimotor activation compared with patients with left arm involvement, although electromyogram across groups was similar; and (3) 2.7-fold–larger contralateral sensorimotor cortex activation, ventrally, in those with full recovery compared with those with partial recovery, despite similar tapping force, frequency, range of motion, and electromyogram between groups. Supplementary motor area activation was unrelated to level of recovery.Conclusions—After stroke that causes mild to moderate initial impairment and mild residual hand weakness, cortical organization varies with side of injury and with final motor status. The findings may have implications for treatment after stroke.(Stroke. 2003; 34: e23-e28.)