Pyroptosis at the forefront of anticancer immunity.
Pyroptosis at the forefront of anticancer immunity.
复制标题
在抗癌免疫的最前沿。
DOI：
10.1186/s13046-021-02065-8
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发表时间：
2021-08-24
期刊：
影响因子：
--
通讯作者：
Teng Y
中科院分区：
文献类型：
--
作者：
Loveless R;Bloomquist R;Teng Y
肿瘤对细胞凋亡的抗性和免疫抑制性肿瘤微环境是癌症干预期间治疗反应差的两个主要因素。细胞凋亡是一种与细胞凋亡不同的裂解性和炎症性程序性细胞死亡途径，随后引起了癌症研究人员的极大兴趣，因为它有可能被临床利用并解决这些问题。最近的证据表明，肿瘤细胞中的焦亡诱导导致强烈的炎症反应和显著的肿瘤消退。在其抗肿瘤作用的基础上，焦亡是由成孔gasdermin蛋白介导的，该蛋白通过细胞破裂后释放促炎细胞因子和免疫原性物质来促进免疫细胞激活和浸润。然而，考虑到其炎性性质，异常的焦亡也可能与肿瘤支持性微环境的形成有关，如某些癌症中gasdermin蛋白的上调所证明的。在这篇综述中，介绍了导致焦亡的分子途径，然后概述了焦亡和癌症之间看似纠缠的联系。我们描述了什么是已知的关于细胞凋亡对抗癌免疫的影响，并提供洞察利用细胞凋亡作为一种工具，并将其应用于新的或现有的抗癌策略的潜力。
Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a lytic and inflammatory programmed cell death pathway distinct from apoptosis, has subsequently sparked notable interest among cancer researchers for its potential to be clinically harnessed and to address these problems. Recent evidence indicates that pyroptosis induction in tumor cells leads to a robust inflammatory response and marked tumor regression. Underlying its antitumor effect, pyroptosis is mediated by pore-forming gasdermin proteins that facilitate immune cell activation and infiltration through their release of pro-inflammatory cytokines and immunogenic material following cell rupture. Considering its inflammatory nature, however, aberrant pyroptosis may also be implicated in the formation of a tumor supportive microenvironment, as evidenced by the upregulation of gasdermin proteins in certain cancers. In this review, the molecular pathways leading to pyroptosis are introduced, followed by an overview of the seemingly entangled links between pyroptosis and cancer. We describe what is known regarding the impact of pyroptosis on anticancer immunity and give insight into the potential of harnessing pyroptosis as a tool and applying it to novel or existing anticancer strategies.
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影响因子：
9
作者：
Chen C;Wang B;Sun J;Na H;Chen Z;Zhu Z;Yan L;Ren S;Zuo Y
通讯作者：
Zuo Y
影响因子：
9
作者：
Fucikova J;Kepp O;Kasikova L;Petroni G;Yamazaki T;Liu P;Zhao L;Spisek R;Kroemer G;Galluzzi L
通讯作者：
Galluzzi L
影响因子：
5.7
作者：
Akino, Kimishige;Toyota, Minoru;Tokino, Takashi
通讯作者：
Tokino, Takashi
DOI：
10.1073/pnas.1016814108
发表时间：
2010-12-14
影响因子：
11.1
作者：
Hu, Bo;Elinav, Eran;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
影响因子：
28.2
作者：
Erkes, Dan A.;Cai, Weijia;Aplin, Andrew E.
通讯作者：
Aplin, Andrew E.