Greater Volume but not Higher Density of Abdominal Aortic Calcium Is Associated With Increased Cardiovascular Disease Risk: MESA (Multi-Ethnic Study of Atherosclerosis).
Greater Volume but not Higher Density of Abdominal Aortic Calcium Is Associated With Increased Cardiovascular Disease Risk: MESA (Multi-Ethnic Study of Atherosclerosis).
复制标题
DOI：
10.1161/circimaging.116.005138
复制
发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Criqui MH
中科院分区：
文献类型：
--
作者：
Forbang NI;Michos ED;McClelland RL;Remigio-Baker RA;Allison MA;Sandfort V;Ix JH;Thomas I;Rifkin DE;Criqui MH
Abdominal aortic calcium (AAC) and coronary artery calcium (CAC) independently and similarly predict cardiovascular disease (CVD) events. The standard AAC and CAC score, the Agatston method, up-weights for greater calcium density, thus models higher calcium density as a CVD hazard. Computed tomography scans were used to measure AAC and CAC volume and density in a multi-ethnic cohort of community dwelling individuals, and Cox-proportional hazard was used to determine their independent association with incident coronary heart disease (CHD, defined as myocardial infarction, and resuscitated cardiac arrest, or CHD death), cardiovascular disease (CVD, defined as CHD plus stroke and stroke death), and all-cause mortality (ACM). In 997 participants with Agatston AAC and CAC scores > 0, mean age was 66 ± 9 years and 58% were men. Over an average follow-up of 9 years, there were 77 CHD, 118 CVD, and 169 ACM events. In mutually adjusted models, additionally adjusted for CVD risk factors, an increase in ln(AAC volume) per standard deviation (SD) was significantly associated with increased ACM (HR=1.25, 95% CI 1.38, 1.42, P<0.01), and an increase ln(CAC volume) per SD was significantly associated with CHD (HR=1.17, 95% CI 1.04, 1.59, P=0.02) and CVD (HR=1.20, 95% CI 1.05, 1.36, P<0.01). In contrast, both AAC and CAC density were not significantly associated with CVD events. The Agatston method of up-weighting calcium scores for greater density may be inappropriate for CVD risk prediction in both the abdominal aorta and coronary arteries.
