Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome
Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome
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DOI：
10.1021/acsnano.5b06175
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发表时间：
2016-02-01
期刊：
影响因子：
17.1
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
--
作者：
Li, Wei-Peng;Su, Chia-Hao;Yeh, Chen-Sheng
超声技术已被广泛用于诊断目的。由于其低成本、易获取和非侵入性的实时成像的特点，在临床实践中，简单地使用诊断超声来同时进行成像和治疗是人们高度期待的。我们报告了一个充满过氧化氢的聚合体，以显示回声反射率和活性氧物种介导的癌症治疗，简单地由伴随磁共振成像的显微超声诊断系统触发。不是填充普通的全氟化碳，而是将过氧化氢包裹在过氧化氢/Fe3O4中。PLGA聚合体提供O-2作为回声来源，(OH)-O-中心点作为治疗元件。在超声波作用下，通过H_2O_2和Fe_3O_4的Fenton反应，聚合体很容易被破坏，生成(OH)-O-中心点。我们证明了恶性肿瘤可以在非热疗过程中完全移除。
Ultrasound techniques have been extensively employed for diagnostic purposes. Because of its features of low cost, easy access, and noninvasive real-time imaging, toward clinical practice it is highly anticipated to simply use diagnostic ultrasound to concurrently perform imaging and therapy. We report a H2O2-filled polymersome to display echogenic reflectivity and reactive oxygen species-mediated cancer therapy simply triggered by the microultrasound diagnostic system accompanied by MR imaging. Instead of filling common perfluorocarbons, the encapsulation of H2O2 in H2O2/Fe3O4. PLGA polymersome provides O-2 as the echo genic source and (OH)-O-center dot as the therapeutic element. On exposure to ultrasound, the polymersome can be easily disrupted to yield (OH)-O-center dot through the Fenton reaction by reaction of H2O2 and Fe3O4. We showed that malignant tumors can be completely removed in a nonthermal process.