Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways.
Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways.
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DOI：
10.4049/jimmunol.1600574
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发表时间：
2016-09-15
期刊：
影响因子：
--
通讯作者：
Carr DJ
中科院分区：
文献类型：
--
作者：
Royer DJ;Conrady CD;Carr DJ
Type I interferon (IFNα/β)-driven immune responses to acute viral infection are critical to counter replication and prevent dissemination. However, the mechanisms underlying host resistance to herpes simplex virus type 1 (HSV-1) are incompletely understood. Here we show that mice with deficiencies in IFNα/β signaling or STING exhibit exacerbated neurovirulence and atypical lymphotropic dissemination of HSV-1 following ocular infection. Synergy between IFNα/β signaling and efficacy of early adaptive immune responses to HSV-1 were dissected using bone marrow chimeras and adoptive cell transfer approaches to profile clonal expansion, effector function, and recruitment of HSV-specific CD8+ T cells. Lymphotropic viral dissemination was commensurate with abrogated CD8+ T cell responses and pathological alterations of fibroblastic reticular cell (FRC) networks in the draining lymph nodes. Our results show that resistance to HSV-1 in the TG during acute infection is conferred in part by STING and IFNα/β-signaling in both bone marrow-derived and resident cells, which coalesce to support a robust HSV-1-specific CD8+ T cell response.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
6.7
作者：
Archer KA;Durack J;Portnoy DA
通讯作者：
Portnoy DA
影响因子：
4.4
作者：
Conrady, Christopher D.;Thapa, Manoj;Carr, Daniel J. J.
通讯作者：
Carr, Daniel J. J.
DOI：
10.1369/jhc.2009.953604
发表时间：
2010-01-01
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
--
作者：
Dai, Xiangchen;Zhu, Bao Ting
通讯作者：
Zhu, Bao Ting
DOI：
10.4049/jimmunol.1203265
发表时间：
2013-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Conrady CD;Zheng M;van Rooijen N;Drevets DA;Royer D;Alleman A;Carr DJ
通讯作者：
Carr DJ