Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide
Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide
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DOI：
10.1080/10715760601169679
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Miyamoto, Yusei
中科院分区：
文献类型：
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作者：
Kajita, Masashi;Hikosaka, Keisuke;Miyamoto, Yusei
采用柠檬酸还原法制备金和铂双金属纳米颗粒，并与果胶互补稳定(Cp-Au/Pt)。铂的摩尔比在0~100%之间变化。Cp-Au/Pt为合金结构。它们很好地分散在水中。铂纳米粒子的平均直径为4.7+/-1.5 nm。过氧化氢(H_2O_2)可被铂含量大于50%的Cp-Au/Pt猝灭，而超氧阴离子自由基(O-2(-))可被任何Cp-Au/Pt猝灭。Cp-Au/Pt对这两种活性氧物种的猝灭作用呈剂量依赖关系。Cp-Pt是最强的猝灭剂。Cp-PT分解H_2O_2生成类O-2过氧化氢酶。用超氧化物歧化酶(SOD)试剂盒验证了CP-铂对O-2，(-)的猝灭作用。这种对O-2(-)的猝灭活性像超氧化物歧化酶一样持续存在。综上所述，Cp-Pt可能是一种超氧化物歧化酶/过氧化氢酶模拟物，可用于氧化应激疾病的药物治疗。
Bimetallic nanoparticles consisting of gold and platinum were prepared by a citrate reduction method and complementarily stabilized with pectin (CP-Au/Pt). The percent mole ratio of platinum was varied from 0 to 100%. The CP-Au/Pt were alloy-structured. They were well dispersed in water. The average diameter of platinum nanoparticles (CP-Pt) was 4.7 +/- 1.5 nm. Hydrogen peroxide (H2O2) was quenched by CP-Au/Pt consisting of more than 50% platinum whereas superoxide anion radical (O-2(-)) was quenched by any CP-Au/Pt. The CP-Au/Pt quenched these two reactive oxygen species in dose-dependent manners. The CP-Pt is the strongest quencher. The CP-Pt decomposed H2O2 and consequently generated O-2 like catalase. The CP-Pt actually quenched O-2,(-) which was verified by a superoxide dismutase (SOD) assay kit. This quenching activity against O-2(-) persisted like SOD. Taken together, CP-Pt may be a SOD/catalase mimetic which is useful for medical treatment of oxidative stress diseases.