Investigation of autoantibody profiles for cerebrospinal fluid biomarker discovery in patients with relapsing-remitting multiple sclerosis
Investigation of autoantibody profiles for cerebrospinal fluid biomarker discovery in patients with relapsing-remitting multiple sclerosis
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DOI：
10.1016/j.jneuroim.2011.08.013
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发表时间：
2012-01-18
影响因子：
3.3
通讯作者：
Heegaard, Niels H. H.
中科院分区：
文献类型：
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作者：
Beyer, Natascha Helena;Lueking, Angelika;Heegaard, Niels H. H.
采用UNIarray (R)标记技术平台，研究了15例对照组和17例RRMS患者脑脊液免疫球蛋白G对人重组蛋白的反应性。患者脑脊液为寡克隆带阳性，反应性与性别和年龄匹配的对照组进行比较。因此，我们的目的是表征RRMS患者的自身反应性。对照和RRMS样品之间的自身反应性差异由本研究中鉴定的自身抗原和先前报道的自身抗原组成。10-15种最重要的蛋白质的组合可以进一步作为诊断目的的自身抗原进行研究。额外的调查可能包括在这种诊断试验中尽量减少使用的蛋白质数量。(C) 2011 Elsevier B.V.版权所有
Using the UNIarray (R) marker technology platform, cerebrospinal fluid immunoglobulin G reactivities of 15 controls and 17 RRMS patients against human recombinant proteins were investigated. Patient cerebrospinal fluids were oligoclonal band positive and reactivities were compared to that of sex- and age-matched controls. We hereby aimed at the characterization of autoreactivity in patients with RRMS. Differences in auto-reactivities between control and RRMS samples were identified comprising autoantigens identified in this study only and previously reported autoantigens as well. A combination of the 10-15 most significant proteins may be investigated further as autoantigens for diagnostic purposes. Additional investigations may include minimizing the number of proteins used in such diagnostic tests. (C) 2011 Elsevier B.V. All rights reserved.