Ultrastructural identification of neuropeptides in the central nervous system.
Ultrastructural identification of neuropeptides in the central nervous system.
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DOI：
10.1002/jemt.1060150107
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发表时间：
1990-05
期刊：
影响因子：
--
通讯作者：
B. Maley
中科院分区：
文献类型：
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作者：
B. Maley
在中枢神经系统的超微结构水平的突触前末梢内已经描述了许多不同的神经肽。这些神经肽中的大多数彼此具有共同的形态。含有神经肽的末端具有一群与突触活性区相关的小而透明的囊泡，以及少量位于距突触活性位点一定距离的大的颗粒状囊泡。据信，大的颗粒状囊泡充当神经肽运输/储存的机制，而小而透明的囊泡被认为充当负责将神经递质/神经肽释放到突触间隙的结构。含神经肽的末端最常具有与其突触前膜相关的不对称连接，尽管在中枢神经系统的许多区域中已经描述了含肽末端的对称连接。含有神经肽的末端接触神经元膜的每个部分；然而，大多数突触接触涉及树突轴的部分。越来越多的证据表明，某些神经肽沿着神经元膜的终止存在特定的空间排列。
A number of different neuropeptides have been described within presynaptic terminals at the ultrastructural level in the central nervous system. The majority of these neuropeptides share a common morphology with one another. Terminals containing neuropeptides have a population of small, clear vesicles associated with the active zone of the synapse and a lesser number of large, granular vesicles that are located at a distance from the active site of the synapse. It is believed that the large, granular vesicles act as a mechanism for the transport/storage of the neuropeptides, while the small, clear vesicles are thought to be acting as structures responsible for the release of the neurotransmitter/neuropeptide into the synaptic cleft. The neuropeptide containing terminals most often have asymmetrical junctions associated with their presynaptic membranes, although symmetrical junctions have been described with peptide containing terminals in a number of areas in the central nervous system. Neuropeptide containing terminals contact every part of the neuronal membrane; however, the majority of synaptic contacts involve portions of the dendritic shafts. Evidence is beginning to accumulate to indicate that for certain neuropeptides there is a specific spatial arrangement to their termination along the neuronal membrane.