Repeated Photobiomodulation Induced Reduction of Bilateral Cortical Hemodynamic Activation During a Working Memory Task in Healthy Older Adults
Repeated Photobiomodulation Induced Reduction of Bilateral Cortical Hemodynamic Activation During a Working Memory Task in Healthy Older Adults
复制标题
DOI：
10.1109/jbhi.2023.3259069
复制
发表时间：
2023-03
影响因子：
7.7
通讯作者：
Zhishan Hu;Xiujuan Qu;Lexuan Li;Xiaohan Zhou;Qin Yang;Qi Dong;Hesheng Liu;Xiaobo Li;Ying Han;Haijing Niu
中科院分区：
文献类型：
--
作者：
Zhishan Hu;Xiujuan Qu;Lexuan Li;Xiaohan Zhou;Qin Yang;Qi Dong;Hesheng Liu;Xiaobo Li;Ying Han;Haijing Niu
经颅光生物调节（tPBM）是一种新兴的非侵入性光神经调节技术，在改善老年人的工作记忆（WM）表现方面显示出很大的潜力。然而，与tPBM相关的神经生理学机制，其基础是WM的改善和这种改善的持续性尚未研究。招募61名健康老年人接受基线假刺激，然后进行为期一周的主动tPBM（每天12分钟，1064 nm激光，250 mW/cm 2）和为期三周的随访。在基线刺激后、活性治疗的第1天（第1天）和第7天（第7天）以及随访时进行N-back WM任务。在任务期间，功能近红外光谱（fNIRS）成像记录皮质血流动力学的变化。将活动和随访期间的脑激活与基线进行比较，以确定tPBM如何改变皮质血流动力学活动以及这些变化持续多久。我们发现，tPBM刺激在第1天诱导显著减少激活的右半球在3回。活动减少从第1天的仅右半球扩展到第7天的两个半球。右侧缘上回和左侧角回的激活减少持续了一周，左侧躯体感觉联合皮层持续了两周。这些激活的变化伴随着显着提高任务的准确性在N-back。这些发现为理解tPBM后认知增强的神经机制提供了重要证据。
Transcranial photobiomodulation (tPBM) is an emerging non-invasive light-based neuromodulation technique that shows promising potential for improving working memory (WM) performance in older adults. However, the neurophysiological mechanisms associated with tPBM that underlie the improvement of WM and the persistence of such improvement have not been investigated. Sixty-one healthy older adults were recruited to receive a baseline sham stimulation, followed by one-week active tPBM (12 min daily, 1064-nm laser, 250 mW/cm2) and three-week follow-ups. N-back WM task was conducted on post-stimulation of the baseline, the first (Day 1) and seventh (Day 7) days of the active treatment, and at the follow-ups. During the task, functional near-infrared spectroscopy (fNIRS) imaging was employed to record the cortical hemodynamic changes. Brain activations during the active and follow-up sessions were compared with the baseline to determine how tPBM had changed cortical hemodynamic activity and how long these changes persisted. We found that tPBM stimulation on Day 1 induced significantly decreased activation in the right hemisphere during the 3-back. The decreased activation expanded from only the right hemisphere on Day 1 to both hemispheres on Day 7. The decreased activation persisted for one week in the right supramarginal gyrus and the left angular gyrus and two weeks in the left somatosensory association cortex. These activation changes were accompanied by significantly improved task accuracy during the N-back. These findings provide important evidence for understanding neural mechanisms underlying cognitive enhancement after tPBM.