Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens.
Ascorbic Acid-Mediated Modulation of Antibiotic Susceptibility of Major Bovine Mastitis Pathogens.
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DOI：
10.2147/idr.s388023
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发表时间：
2022
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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本研究旨在研究抗坏血酸对奶牛乳房炎主要病原菌（包括金黄色葡萄球菌、停乳链球菌、链球菌、无乳链球菌和大肠杆菌）抗生素敏感性的影响。最小抑菌浓度（MIC）采用E-test法测定。10 mM抗坏血酸的存在降低了青霉素和氨苄青霉素的MIC，同时增加了红霉素、卡那霉素、链霉素和环丙沙星对所有测试菌株的MIC。此外，抗坏血酸特异性降低四环素对革兰氏阳性菌和氯霉素对革兰氏阴性菌的MIC。这项研究强调，抗坏血酸是一种潜在的调节剂的抗生素活性对主要的牛乳房炎病原体。
This study aimed to investigate the effects of ascorbic acid on antibiotic susceptibility of major bovine mastitis pathogens, including Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus uberis, Streptococcus agalactiae, and Escherichia coli. Minimum inhibitory concentrations (MICs) were determined by E-test method. The presence of 10 mM ascorbic acid decreased the MICs of penicillin and ampicillin while increased the MICs of erythromycin, kanamycin, streptomycin, and ciprofloxacin for all tested strains. Besides, ascorbic acid specifically reduced the MICs of tetracycline for gram-positive bacteria and chloramphenicol for gram-negative bacteria. This study highlights that ascorbic acid is a potential modulator of antibiotic activity against the major bovine mastitis pathogens.