The effects of PM2.5 on asthmatic and allergic diseases or symptoms in preschool children of six Chinese cities, based on China, Children, Homes and Health (CCHH) project
The effects of PM2.5 on asthmatic and allergic diseases or symptoms in preschool children of six Chinese cities, based on China, Children, Homes and Health (CCHH) project
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DOI：
10.1016/j.envpol.2017.08.072
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发表时间：
2018-01-01
影响因子：
8.9
通讯作者：
Zhao, Zhuohui
中科院分区：
文献类型：
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作者：
Chen, Fei'er;Lin, Zhijing;Zhao, Zhuohui
中国的城市化和工业化伴随着恶劣的空气质量，近年来中国儿童哮喘的患病率不断增加。为了研究中国学龄前儿童环境PM2.5水平与哮喘和过敏性疾病或症状之间的关系，我们将全球疾病负担（GBD）项目的PM2.5暴露数据分配给中国六个城市（上海，南京，重庆，长沙，乌鲁木齐和太原）的205所幼儿园，空间分辨率为0.1度x 0.1度。采用分层多元逻辑回归模型分析了10年PM2.5暴露水平与哮喘和过敏症状个体水平结局之间的相关性。调整了个人水平变量（包括性别、年龄、哮喘和过敏性疾病家族史、母乳喂养、父母吸烟、室内湿度、室内装修污染、家庭年收入）和城市水平变量（年气温）。共有30，759名儿童（平均年龄4.6岁，51.7%为男孩）入组本研究。除了家族史、室内潮湿和装修是主要的危险因素外，我们发现，每年PM2.5增加10 μ g/m3与变应性鼻炎的患病率呈正相关，比值比（OR）为1.20（95%置信区间[CI] 1.11，1.29）和诊断哮喘的OR为1.10（95% CI 1.03，1.18）。那些居住在非城市（与城市）地区的人暴露于生物质燃烧产生的更严重的室内空气污染，并且PM2.5与过敏性鼻炎和当前鼻炎之间的OR显着较高。我们的研究表明，长期暴露于PM2.5可能会增加中国学龄前儿童患哮喘和过敏性疾病或症状的风险。与生活在城市地区的儿童相比，生活在郊区或农村地区的儿童接触PM2.5的风险更高。(C)2017爱思唯尔有限公司版权所有
The urbanization and industrialization in China is accompanied by bad air quality, and the prevalence of asthma in Chinese children has been increasing in recent years. To investigate the associations between ambient PM2.5 levels and asthmatic and allergic diseases or symptoms in preschool children in China, we assigned PM2.5 exposure data from the Global Burden of Disease (GBD) project to 205 kindergartens at a spatial resolution of 0.1 degrees x 0.1 degrees in six cities in China (Shanghai, Nanjing, Chongqing, Changsha, Urumqi, and Taiyuan). A hierarchical multiple logistical regression model was applied to analyze the associations between kindergarten-level PM2.5 exposure and individual-level outcomes of asthmatic and allergic symptoms. The individual-level variables, including gender, age, family history of asthma and allergic diseases, breastfeeding, parental smoking, indoor dampness, interior decoration pollution, household annual income, and city-level variable-annual temperature were adjusted. A total of 30,759 children (average age 4.6 years, 51.7% boys) were enrolled in this study. Apart from family history, indoor dampness, and decoration as predominant risk factors, we found that an increase of 10 mu g/m(3) of the annual PM2.5 was positively associated with the prevalence of allergic rhinitis by an odds ratio (OR) of 1.20 (95% confidence interval [CI] 1.11, 1.29) and diagnosed asthma by OR of 1.10 (95% CI 1.03, 1.18). Those who lived in non-urban (vs. urban) areas were exposed to more severe indoor air pollution arising from biomass combustion and had significantly higher ORs between PM2.5 and allergic rhinitis and current rhinitis. Our study suggested that long-term exposure to PM2.5 might increase the risks of asthmatic and allergic diseases or symptoms in preschool children in China. Compared to those living in urban areas, children living in suburban or rural areas had a higher risk of PM2.5 exposure. (C) 2017 Elsevier Ltd. All rights reserved.