Central body fatness is a stronger predictor of cancer risk than overall body size
Central body fatness is a stronger predictor of cancer risk than overall body size
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DOI：
10.1038/s41467-018-08159-w
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发表时间：
2019-01-22
影响因子：
16.6
通讯作者：
Brenner, Darren R.
中科院分区：
文献类型：
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作者：
Barberio, Amanda M.;Alareeki, Asalah;Brenner, Darren R.
体型和体重分布对癌症风险的重要性尚不清楚。我们调查了身体大小和形状与患癌症风险之间的关系。研究人群包括来自阿尔伯塔省明天项目队列的26,607名参与者。检查了两种主要的体型和尺寸测量方法：1)身体质量指数（BMI）和2)腰围（WC）。通过与阿尔伯塔癌症登记处的联系，确定了偶发性癌症。采用Cox比例风险模型。被归类为肥胖的男性和女性（体重指数>= 30 kg/m(-2)）患所有癌症的风险分别比体重正常的人高33%和22%。类似的所有癌症的风险增加观察到以上性别的WC指南。体重的相互调整减弱了BMI与所有癌症风险之间的联系，尤其是在女性中。中心性肥胖似乎比体型更能预测患各种癌症的风险。
The importance of body size versus weight distribution for cancer risk is unclear. We investigated associations between measures of body size and shape and the risk of developing cancer. The study population consisted of 26,607 participants from the Alberta's Tomorrow Project cohort. Two main measures of body shape and size were examined: i) body mass index (BMI) and ii) waist circumference (WC). Incident cancers were identified via linkage to the Alberta Cancer Registry. Cox proportional hazards models were used. Males and females classified as obese (BMI >= 30 kg/m(-2)) have a 33% and 22% increased risk of all-cancer, respectively, than their normal weight counterparts. Similar all-cancer risk increases are observed for those above sex-specific WC guidelines. Mutual adjustment for WC attenuates the association between BMI and all-cancer risk, especially among females. Central adiposity appears to be a stronger predictor of all-cancer risk than body size.