A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, China
A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, China
复制标题
DOI：
10.1086/504943
复制
发表时间：
2006-07-01
影响因子：
11.8
通讯作者：
Yuen, Kwok-Yung
中科院分区：
文献类型：
--
作者：
Che, Xiao-yan;Di, Biao;Yuen, Kwok-Yung
2004年初，在中国广州的一次SARS社区暴发期间，发生了一例无症状的严重急性呼吸系统综合征（SARS）病例。这是首次在有抗原血症和血清转换的个体中发现无症状SARS病例。2003-2004年爆发的SARS无症状病例患者和第二例指示病例患者都在同一家餐馆工作，他们供应的棕榈果子狸被发现携带与SARS相关的冠状病毒。流行病学信息和实验室结果表明，对无症状感染患者的调查结果，以及先前报告的对野生动物处理者和2004年社区暴发的4例指示病例患者的血清学分析结果，反映了可能是动物-人传播的中间阶段，而不是人-人传播的病例。这一中间阶段可能是病毒进化和疾病预防的关键阶段。
An asymptomatic case of severe acute respiratory syndrome ( SARS) occurred early in 2004, during a community outbreak of SARS in Guangzhou, China. This was the first time that a case of asymptomatic SARS was noted in an individual with antigenemia and seroconversion. The asymptomatic case patient and the second index case patient with SARS in the 2003-2004 outbreak both worked in the same restaurant, where they served palm civets, which were found to carry SARS-associated coronaviruses. Epidemiological information and laboratory findings suggested that the findings for the patient with asymptomatic infection, together with the findings from previously reported serological analyses of handlers of wild animals and the 4 index case patients from the 2004 community outbreak, reflected a likely intermediate phase of animal-to-human transmission of infection, rather than a case of human-to-human transmission. This intermediate phase may be a critical stage for virus evolution and disease prevention.