Early consciousness disorder in acute ischemic stroke: incidence, risk factors and outcome.
Early consciousness disorder in acute ischemic stroke: incidence, risk factors and outcome.
复制标题
急性缺血性卒中的早期意识障碍：发病率、危险因素和结果
DOI：
10.1186/s12883-016-0666-4
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发表时间：
2016-08-17
期刊：
影响因子：
2.6
通讯作者：
Liu M
中科院分区：
文献类型：
--
作者：
Li J;Wang D;Tao W;Dong W;Zhang J;Yang J;Liu M
BackgroundLittle是已知的发病率和危险因素的早期意识障碍（ECD）在急性缺血性卒中患者，或如何ECD可能会影响并发症和outcome.MethodsPatients入院24小时内急性缺血性卒中发病连续登记。ECD的临床评价和使用格拉斯哥昏迷量表。多变量分析用于确定ECD的危险因素，以及ECD和临床outcomes.ResultsOf的569例患者入组，199（35%）有ECD之间的关联。ECD的独立危险因素为高龄（OR 1.027，95%CI 1.007 ~ 1.048）、入院时美国国立卫生研究院卒中评分（OR 1.331，95%CI 1.257 ~ 1.410）和大面积脑梗死（OR 3.211，95%CI 1.642 ~ 6.279）。ECD与卒中相关并发症的发生率（83.4%vs.31.1%，P< 0.001）和住院死亡率（17.1%vs.0.5%，P< 0.001）相关。ECD独立预测3个月死亡/残疾（OR 3.272，95%CI 1.670 ~ 6.413）。危险因素包括高龄、中风严重程度和大面积脑梗死。ECD与卒中相关并发症和3个月死亡/残疾的频率较高相关。
BackgroundLittle is known about the incidence and risk factors of early consciousness disorder (ECD) in patients with acute ischemic stroke, or about how ECD may affect complications and outcomes.MethodsPatients admitted to our hospital within 24 h of onset of acute ischemic stroke were consecutively enrolled. ECD was evaluated clinically and using the Glasgow coma scale. Multivariate analysis was used to identify risk factors of ECD, as well as associations between ECD and clinical outcomes.ResultsOf the 569 patients enrolled, 199 (35 %) had ECD. Independent risk factors of ECD were advanced age (OR 1.027, 95 % CI 1.007 to 1.048), National Institutes of Health Stroke Score on admission (OR 1.331, 95 % CI 1.257 to 1.410), and massive cerebral infarct (OR 3.211, 95 % CI 1.642 to 6.279). ECD was associated with higher frequency of stroke-related complications (83.4 % vs. 31.1 %,P< 0.001) and higher in-hospital mortality (17.1 % vs. 0.5 %,P< 0.001). ECD independently predicted 3-month death/disability (OR 3.272, 95 % CI 1.670 to 6.413).ConclusionsECD is prevalent in Chinese patients with acute ischemic stroke. Risk factors include advanced age, stroke severity, and massive cerebral infarct. ECD is associated with higher frequency of stroke-related complications and 3-month death/disability.