Omega-3 Polyunsaturated Fatty Acids: Versatile Roles in Blood Pressure Regulation
Omega-3 Polyunsaturated Fatty Acids: Versatile Roles in Blood Pressure Regulation
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Omega-3 多不饱和脂肪酸：在血压调节中的多种作用
DOI：
10.1089/ars.2020.8108
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发表时间：
2020
影响因子：
6.6
通讯作者：
Zhang Xu
中科院分区：
文献类型：
--
作者：
Wang Hui;Li Qi;Zhu Yi;Zhang Xu
意义：高血压的特征是血管收缩和血管扩张的失衡。高血压受遗传变异和环境风险因素的影响，如不健康的饮食。临床试验结果表明，增加摄入富含n-3多不饱和脂肪酸(PUFAs)的食物有利于高血压。最近的进展：我们总结了最近关于补充n-3PUFAs来降低高血压(BP)的临床试验，并系统地讨论了n-3PUFAs/n-3加氧脂的降压机制，包括减少氧化应激，改变膜相关蛋白的功能，以及与n-6PUFAs/n-6加氧脂竞争调节血管扩张剂的释放。关键问题：以前的研究认为n-3PUFAs是在高血压中具有有益作用的单分子。近年来，n-3多不饱和脂肪酸的代谢受到了越来越多的关注，并对n-3多不饱和脂肪酸及其衍生的氧合脂在高血压干预中的分子机制进行了探讨。未来的研究方向：根据n-3多不饱和脂肪酸/n-3氧化脂的代谢和控制血压的机制，我们建议将n-3多不饱和脂肪酸与针对多不饱和脂肪酸代谢或相关信号通路的药物相结合，可能会放大其治疗高血压和其他心血管疾病的作用。抗氧化。氧化还原信号。34,800-810。
Significance:Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich in n-3 polyunsaturated fatty acids (PUFAs) is beneficial for hypertension.Recent Advances:We summarized recent clinical trials regarding supplementation with n-3 PUFAs to reduce blood pressure (BP) in untreated hypertensive and normotensive subjects and systematically discussed the antihypertension mechanisms of n-3 PUFAs/n-3 oxylipins, including reducing oxidative stress, altering functions of membrane-related proteins, and competing with n-6 PUFAs/n-6 oxylipins in regulating vasodilator release.Critical Issues:Previous studies considered n-3 PUFAs as single molecules with beneficial roles in hypertension. Recently, researchers have paid more attention to the metabolism of n-3 PUFAs and explored molecular mechanisms of n-3 PUFAs and oxylipins derived from n-3 PUFAs in hypertension interventions.Future Directions:Based on the metabolism of n-3 PUFAs/n-3 oxylipins and mechanisms in BP control, we suggested that supplementation of n-3 PUFAs combined with agents targeting PUFA metabolism or the related signal pathways may amplify their effects to treat hypertension and other cardiovascular diseases.Antioxid. Redox Signal.34, 800–810.