Mechanosensing in Metabolism.
Mechanosensing in Metabolism.
复制标题
新陈代谢中的机械传感。
DOI：
10.1002/cphy.c230005
复制
发表时间：
2023
影响因子：
5.8
通讯作者：
Sah,Rajan
中科院分区：
文献类型：
--
作者：
Tranter,JohnD;Kumar,Ashutosh;Nair,VinayakK;Sah,Rajan
电机械传感是由专门的离子通道介导的过程，直接或间接地由机械力门控，其允许细胞检测并随后响应机械刺激。机械敏感性（MS）离子通道（由机械力内在门控）或机械响应性（MR）离子通道（由机械力间接门控）的激活导致跨越脂质双层（如质膜）的电信号传导。虽然机械门控通道在感觉环境中的功能（例如，虽然已经很好地描述了触觉和本体感受（包括触觉和本体感受），但是出现了证明触觉和本体感受之外的功能的数据，包括细胞内信号传导和细胞/全身代谢的机械调节。MR和MS离子通道信号传导均已显示有助于调节代谢功能障碍，包括肥胖、胰岛素抵抗、胰岛素分泌受损和炎症。这篇综述总结了我们目前对几种MS/MR离子通道在参与代谢功能障碍的细胞类型（即脂肪细胞、胰腺β细胞、肝细胞和骨骼肌细胞）中的作用的理解，并讨论了MS/MR离子通道作为可能的治疗靶点。© 2024 American Physiological Society.Compr Physiol 14：5269 - 5290，2024.
Electrical mechanosensing is a process mediated by specialized ion channels, gated directly or indirectly by mechanical forces, which allows cells to detect and subsequently respond to mechanical stimuli. The activation of mechanosensitive (MS) ion channels, intrinsically gated by mechanical forces, or mechanoresponsive (MR) ion channels, indirectly gated by mechanical forces, results in electrical signaling across lipid bilayers, such as the plasma membrane. While the functions of mechanically gated channels within a sensory context (e.g., proprioception and touch) are well described, there is emerging data demonstrating functions beyond touch and proprioception, including mechanoregulation of intracellular signaling and cellular/systemic metabolism. Both MR and MS ion channel signaling have been shown to contribute to the regulation of metabolic dysfunction, including obesity, insulin resistance, impaired insulin secretion, and inflammation. This review summarizes our current understanding of the contributions of several MS/MR ion channels in cell types implicated in metabolic dysfunction, namely, adipocytes, pancreatic β‐cells, hepatocytes, and skeletal muscle cells, and discusses MS/MR ion channels as possible therapeutic targets. © 2024 American Physiological Society.Compr Physiol14:5269‐5290, 2024.