Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population.
Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population.
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Basigin rs8259 多态性可降低中国人群慢性心力衰竭的风险
DOI：
10.3390/ijerph14020211
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发表时间：
2017-02-21
影响因子：
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通讯作者：
Chen XP
中科院分区：
文献类型：
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作者：
Li MP;Hu XL;Yang YL;Zhang YJ;Zhou JP;Peng LM;Tang J;Chen XP
左室重构是慢性心力衰竭（CHF）发病的重要危险因素。Basigin（BSG）通过诱导细胞外基质金属蛋白酶和炎性细胞因子促进心血管炎症和心肌重塑过程。BSG rs8259多态性与BSG表达和急性冠脉综合征风险相关。因此，我们研究rs8259多态性是否有助于中国CHF患者的风险和预后。共招募了922名CHF成人患者和1107名匹配的健康对照。采用PCR-限制性片段长度多态性方法对BSG rs8259多态性进行基因分型。获取来自基因型-组织表达项目的全血BSG mRNA表达数据。仅对15.2%（140）的CHF患者进行了随访数据评价。BSG rs8259 TT基因型与CHF风险降低相关（OR = 0.83，95%CI = 0.72-0.96，p = 0.010），尤其是高血压患者（OR = 0.80，95%CI = 0.68-0.95，p = 0.011）和冠心病（OR = 0.81，95%CI = 0.69-0.96，p = 0.013）。在338名健康正常献血者的全血中，Rs8259 T等位基因与BSG mRNA降低相关（p = 1.31 × 10 − 6）。然而，rs8259多态性未能表现出与心血管死亡率的相关性（p = 0.283）。BSG rs8259多态性可能有助于降低中国汉族人群CHF的风险。
Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled. BSG rs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole blood BSG mRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF. BSG rs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72–0.96, p = 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68–0.95, p = 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69–0.96, p = 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreased BSG mRNA in whole blood from 338 healthy normal donors (p = 1.31 × 10−6). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p = 0.283). BSG rs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population.