Neuroblastoma and insulin-like growth factor system - New insights and clinical perspectives
Neuroblastoma and insulin-like growth factor system - New insights and clinical perspectives
复制标题
DOI：
10.1007/s004310050595
复制
发表时间：
1997-04-01
影响因子：
3.6
通讯作者：
Rossi, P
中科院分区：
文献类型：
--
作者：
Cianfarani, S;Rossi, P
同时，神经母细胞瘤是儿童时期最常见和最令人困惑的颅外实体瘤，尽管广泛传播，但能够自发消退，原位形式的发生率惊人地高，最后，甚至对积极的化疗也有抵抗力。由于我们对神经母细胞瘤的病理生理学知之甚少，这种奇怪行为的原因在很大程度上仍然未知。越来越多的证据表明，胰岛素样生长因子系统在神经母细胞瘤细胞的增殖和分化中起着至关重要的作用，可以想象，更好地了解这种作用可能会导致新的和更有效的治疗策略。在这里，我们回顾了最新的见解成神经细胞瘤的生物学，重点与胰岛素样生长因子系统和潜在的临床前景的密切联系。
Neuroblastoma is, at the same time, the most common and the most puzzling extracranial solid tumour in childhood, being able to regress spontaneously despite widespread dissemination, showing a striking high incidence of the in situ form, and, finally, being resistant even to aggressive chemotherapy. The reasons of this bizarre behaviour are still largely unknown due to our little knowledge of neuroblastoma pathophysiology. There is increasing body of evidence that the insulin-like growth factor system plays a crucial role in the proliferation and differentiation of neuroblastoma cells and it is conceivable that a better knowledge of this role might potentially lead to new and more effective therapeutic strategies. Here we review the most recent insights into the biology of neuroblastoma, focusing on the close links with the insulin-like growth factor system and the potential clinical perspectives.