Childhood Obesity and Asthma Control in the GALA II and SAGE II Studies
Childhood Obesity and Asthma Control in the GALA II and SAGE II Studies
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DOI：
10.1164/rccm.201211-2116oc
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发表时间：
2013-04-01
影响因子：
24.7
通讯作者：
Burchard, Esteban G.
中科院分区：
文献类型：
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作者：
Borrell, Luisa N.;Nguyen, Elizabeth A.;Burchard, Esteban G.
理由：肥胖与哮喘发病率升高，对吸入皮质类固醇的药物反应性降低以及哮喘控制较差有关。但是，大多数先前对肥胖和哮喘控制的调查并未集中在儿科人群上，即环境暴露或包括少数族裔儿童。目标：研究男孩和女孩之间体重指数类别与控制哮喘之间的关联；以及这些关联是否通过年龄和种族/种族进行修改。方法：8-19岁的儿童和青少年（n = 2,174）与哮喘的哮喘是从拉丁裔美国人（Gala II）中的基因环境和混合物中招募的，以及对非洲裔美国人，哮喘，基因和环境（Sage II）的研究和研究。顺序逻辑回归用于估计哮喘控制较差的频率比（OR）及其置信区间（OR）及其置信区间（95％CI）。测量和主要结果：在调整后的分析中，肥胖的男孩的哮喘患者比正常体重较差的哮喘控制差33％的机会（OR，1.33; 1.33; 95％CI; 95％CI，1.04-1.71）。但是，对于女孩而言，这种关联随种族和种族而异（P相互作用= 0.008）。与正常的同行相比，肥胖的非洲裔美国女孩（OR，0.65; 95％CI，0.41-1.05）更有可能患有更好的控制哮喘，而墨西哥裔美国人的女孩具有1.91（95％CI（95％CI，1.12-3.28，1.12-3.28）的较差的哮喘对照组的比例更大：较差的男孩的群体相关性。在女孩中，这种协会的方向随种族/种族而异。
Rationale: Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. However, most prior investigations on obesity and asthma control have not focused on pediatric populations, considered environmental exposures, or included minority children.Objectives: To examine the association between body mass index categories and asthma control among boys and girls; and whether these associations are modified by age and race/ethnicity.Methods: Children and adolescents ages 8-19 years (n = 2,174) with asthma were recruited from the Genes-environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes, and Environments (SAGE II). Ordinal logistic regression was used to estimate odds ratios (OR) and their confidence intervals (95% CI) for worse asthma control.Measurements and Main Results: In adjusted analyses, boys who were obese had a 33%-greater chance of having worse asthma control than their normal-weight counterparts (OR, 1.33; 95% CI, 1.04-1.71). However, for girls this association varied with race and ethnicity (P interaction = 0.008). When compared with their normal-weight counterparts, obese African American girls (OR, 0.65; 95% CI, 0.41-1.05) were more likely to have better controlled asthma, whereas Mexican American girls had a 1.91 (95% CI, 1.12-3.28) greater odds of worse asthma control.Conclusions: Worse asthma control is uniformly associated with increased body mass index in boys. Among girls, the direction of this association varied with race/ethnicity.