Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area A 13-Year Follow-Up Study: The Tromso Study
Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area A 13-Year Follow-Up Study: The Tromso Study
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DOI：
10.1161/strokeaha.111.646596
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发表时间：
2012-07-01
期刊：
影响因子：
8.3
通讯作者：
Mathiesen, Ellisiv B.
中科院分区：
文献类型：
--
作者：
Herder, Marit;Johnsen, Stein Harald;Mathiesen, Ellisiv B.
背景和目的：关于内膜中层厚度（IMT）和斑块进展的危险因素的数据很少。目的是确定长期的危险因素，总斑块面积（TPA）和IMT以及危险因素的进展（三角洲TPA和三角洲IMT）。方法受试者是1307名男性和1436名女性谁参加了纵向人口为基础的研究，超声检查的右颈动脉在基线和13年后的后续行动。在基线时获得总胆固醇、高密度脂蛋白胆固醇、血压、体重指数以及有关吸烟习惯、糖尿病患病率和心血管疾病的信息。颈动脉粥样硬化通过颈总动脉无斑块段的TPA和平均IMT进行评估。在多元线性回归模型中评估了危险因素和颈动脉粥样硬化的z分数之间的关联。结果在多变量模型中，总胆固醇、收缩压和吸烟是随访TPA比IMT更强的预测因子，而性别和年龄是IMT更强的预测因子。总胆固醇（标准化β =0.081）、收缩压（标准化β =0.062）和吸烟（标准化β =0.107）是Delta TPA的显著预测因子，而只有总胆固醇（标准化β =0.084）是Delta IMT的独立预测因子。由传统的心血管危险因素解释的方差为TPA比IMT. Conclusions，心血管危险因素总胆固醇，吸烟和收缩压TPA和TPA进展比IMT和IMT进展更强的长期预测。（中风。2012;43：1818-1823.）
Background and Purpose-Data on risk factors for progression of intima-media thickness (IMT) and plaque are scarce. The objective was to determine long-term risk factors for total plaque area (TPA) and IMT as well as risk factors for progression (Delta TPA and Delta IMT).Methods-Subjects were 1307 men and 1436 women who participated in a longitudinal population-based study with ultrasound examination of the right carotid artery at baseline and after 13 years of follow-up. Total cholesterol, high-density lipoprotein cholesterol, blood pressure, body mass index, and information about smoking habits, prevalent diabetes, and cardiovascular disease were obtained at baseline. Carotid atherosclerosis was assessed as TPA and mean IMT of plaque-free segments of the common carotid artery. Associations between z-scores of risk factors and carotid atherosclerosis were assessed in multiple linear regression models.Results-In multivariable models, total cholesterol, systolic blood pressure, and smoking were stronger predictors of follow-up TPA than of IMT, whereas sex and age were stronger predictors of IMT. Total cholesterol (standardized beta=0.081), systolic blood pressure (standardized beta=0.062), and smoking (standardized beta=0.107) were significant predictors of Delta TPA, whereas only total cholesterol (standardized beta=0.084) was an independent predictor of Delta IMT. The variance explained by traditional cardiovascular risk factors was somewhat greater for TPA than for IMT.Conclusions-The cardiovascular risk factors total cholesterol, smoking, and systolic blood pressure were stronger long-term predictors of TPA and TPA progression than for IMT and IMT progression. (Stroke. 2012;43:1818-1823.)