No relation between apolipoprotein E alleles and obstructive sleep apnea
No relation between apolipoprotein E alleles and obstructive sleep apnea
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载脂蛋白E等位基因与阻塞性睡眠呼吸暂停之间没有关系
DOI：
10.1111/j.1399-0004.1998.tb02663.x
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发表时间：
1998
影响因子：
3.5
通讯作者：
Markku M. Nieminen
中科院分区：
文献类型：
--
作者：
S. Saarelainen;T. Lehtimäki;E. Kallonen;K. Laasonen;T. Poussa;Markku M. Nieminen
载脂蛋白E（ApoE）是影响心血管疾病和阿尔茨海默病发展的遗传危险因素。阻塞性睡眠呼吸暂停（OSA）患者的死亡率和心血管疾病的发病率过高。检测了291例OSA患者和728例对照者的ApoE等位基因频率。ApoE等位基因和基因型在OSA组和对照组中的分布无明显差异。
Apolipoprotein E (ApoE) is a genetic risk factor influencing the development of cardiovascular diseases and Alzheimer's disease. Patients with obstructive sleep apnea (OSA) suffer an excess mortality and morbidity from cardiovascular diseases. The frequencies of ApoE alleles were determined in 291 patients with OSA and 728 controls. The distribution of ApoE alleles and genotypes showed no difference between OSA and controls.