Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients
Relevance of Serum Leptin and Leptin-Receptor Concentrations in Critically Ill Patients
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DOI：
10.1155/2010/473540
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发表时间：
2010-01-01
影响因子：
4.6
通讯作者：
Tacke, Frank
中科院分区：
文献类型：
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作者：
Koch, Alexander;Weiskirchen, Ralf;Tacke, Frank
脂肪细胞衍生的细胞因子瘦素与炎症和代谢改变有关。我们研究了瘦素成分在危重患者中的潜在作用，因为全身炎症、胰岛素抵抗和高血糖是危重病的常见特征。在进入医学重症监护室（ICU）后，测定了137例危重患者（95例败血症，42例无败血症）和26例健康对照者的游离瘦素和可溶性瘦素受体血清浓度。血清瘦素或瘦素受体在患者和对照组之间没有差异，并且与脓毒症无关。然而，血清瘦素与肥胖和糖尿病密切相关，并与代谢和肝功能指标明显相关。瘦素受体是一个不利的预后指标，与三年随访期间的死亡率相关。我们的研究表明瘦素在严重疾病的发病机制中的功能作用，并强调了复杂的代谢改变对危重患者临床结局的影响。
The adipocyte-derived cytokine leptin was implicated to link inflammation and metabolic alterations. We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. Upon admission to Medical Intensive Care Unit (ICU), free leptin and soluble leptin-receptor serum concentrations were determined in 137 critically ill patients (95 with sepsis, 42 without sepsis) and 26 healthy controls. Serum leptin or leptin-receptor did not differ between patients or controls and were independent of sepsis. However, serum leptin was closely associated with obesity and diabetes and clearly correlated with markers of metabolism and liver function. Leptin-receptor was an unfavourable prognostic indicator, associated with mortality during three years follow-up. Our study indicates a functional role of leptin in the pathogenesis of severe illness and emphasizes the impact of complex metabolic alterations on the clinical outcome of critically ill patients.